Synthesis and antibacterial activity of some Pyrazoline derivatives

Pyrazoline derivatives, being used as potential medicinal agents, a series P-1-P-5 containing 3,5-diphenylpyrazoline and N-phenyl-3,5-diphenylpyrazoline derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis (MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that P-1 and P-2 possess good antibacterial potential against S. aureus, P-5 against S. epidermidis and P-1 and P-4 against E. coli.