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Synthesis and antibacterial activity of some Pyrazoline derivatives
被引:0
|作者:
Chovatia, Y. S.
[1
]
Gandhi, S. P.
[2
]
Gorde, P. L.
[3
]
Bagade, S. B.
[1
]
机构:
[1] SVKMs NMIMS, Sch Pharm & Technol Management, Shirpur 425405, India
[2] AISSMS, Coll Pharm, Pune 411001, Maharashtra, India
[3] Sanjivani Coll Pharmaceut Educ & Res, Kopargaon, India
关键词:
Pyrazoline;
Disc diffusion method;
Amikacin;
D O I:
暂无
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Pyrazoline derivatives, being used as potential medicinal agents, a series P-1-P-5 containing 3,5-diphenylpyrazoline and N-phenyl-3,5-diphenylpyrazoline derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis (MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that P-1 and P-2 possess good antibacterial potential against S. aureus, P-5 against S. epidermidis and P-1 and P-4 against E. coli.
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页码:275 / 278
页数:4
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