INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS

被引：121

作者：

KORUTLA, L

KUMAR, R

机构：

[1] PENN STATE UNIV,COLL MED,DEPT MED,HERSHEY,PA 17033

[2] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1224卷 / 03期

关键词：

CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KINASE ACTIVITY; A431; CELL;

D O I：

10.1016/0167-4889(94)90299-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.

引用

页码：597 / 600

页数：4

共 50 条

[31] THE ENDOCYTOSIS OF EPIDERMAL GROWTH-FACTOR IN A431 CELLS - A PH OF MICROENVIRONMENT AND THE DYNAMICS OF RECEPTOR COMPLEX DISSOCIATION
SORKIN, AD
TESLENKO, LV
NIKOLSKY, NN
EXPERIMENTAL CELL RESEARCH, 1988, 175 (01) : 192 - 205
[32] EFFECTS OF EPIDERMAL GROWTH-FACTOR RECEPTOR CONCENTRATION ON TUMORIGENICITY OF A431 CELLS IN NUDE-MICE
SANTON, JB
CRONIN, MT
MACLEOD, CL
MENDELSOHN, J
MASUI, H
GILL, GN
CANCER RESEARCH, 1986, 46 (09) : 4701 - 4705
[33] ASPECTS OF THE METABOLISM OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN A431 HUMAN EPIDERMOID CARCINOMA-CELLS
DECKER, SJ
MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (04) : 571 - 575
[34] PRESENCE OF LYSOGLYCOSPHINGOLIPIDS IN A431 CELLS - THEIR INHIBITION OF TYROSINE PHOSPHORYLATION OF EPIDERMAL GROWTH-FACTOR (EGF) RECEPTOR
HANAI, N
NORES, G
HAKOMORI, S
FEDERATION PROCEEDINGS, 1987, 46 (06) : 1926 - 1926
[35] TYROSINE KINASE-ACTIVITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN GASTRIC CARCINOMAS
KAMEDA, T
YASUI, W
TSUJINO, T
NAKAYAMA, H
AYHAN, A
ITO, H
TAHARA, E
PATHOLOGY RESEARCH AND PRACTICE, 1992, 188 (1-2) : 37 - 43
[36] PHOSPHORYLATION AND TYROSINE KINASE-ACTIVITY OF THE INTERNALIZED EPIDERMAL GROWTH-FACTOR RECEPTOR COMPLEX
RESHETNIKOVA, GF
NESTEROV, AM
NIKOLSKY, NN
TSITOLOGIYA, 1990, 32 (02): : 140 - &
[37] EPIDERMAL GROWTH-FACTOR TREATMENT OF A431 CELLS ALTERS THE BINDING-CAPACITY AND ELECTROPHORETIC MOBILITY OF THE CYTOSKELETALLY ASSOCIATED EPIDERMAL GROWTH-FACTOR RECEPTOR
ROY, LM
GITTINGER, CK
LANDRETH, GE
JOURNAL OF CELLULAR PHYSIOLOGY, 1991, 146 (01) : 63 - 72
[38] EPIDERMAL GROWTH-FACTOR INDUCES TYROSINE PHOSPHORYLATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS NOT OCCUPIED WITH LIGAND IN INTACT A431 CELLS
SOROKIN, AB
RESHETNIKOVA, GF
KUDRYAVTSEVA, NV
NIKOLSKY, NN
FEBS LETTERS, 1990, 268 (01) : 121 - 124
[39] RECYCLING OF EPIDERMAL GROWTH FACTOR-RECEPTOR COMPLEXES IN A431 CELLS
SORKIN, A
KORNILOVA, E
TESLENKO, L
SOROKIN, A
NIKOLSKY, N
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1011 (01) : 88 - 96
[40] RECYCLING OF EPIDERMAL GROWTH FACTOR-RECEPTOR COMPLEXES IN A431 CELLS
SORKIN, AD
BOGDANOVA, NP
SOROKIN, AB
TESLENKO, LV
NIKOLSKY, NN
TSITOLOGIYA, 1989, 31 (03): : 300 - +

← 1 2 3 4 5 →