INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS

被引：121
|
作者：
KORUTLA, L
KUMAR, R
机构：
[1] PENN STATE UNIV,COLL MED,DEPT MED,HERSHEY,PA 17033
[2] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1224卷 / 03期
关键词：
CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KINASE ACTIVITY; A431; CELL;
D O I：
10.1016/0167-4889(94)90299-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.
引用
收藏
页码：597 / 600
页数：4
相关论文
共 50 条
  • [21] INHIBITION OF EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE-ACTIVITY BY HYPERICIN
    DEWITTE, P
    AGOSTINIS, P
    VANLINT, J
    MERLEVEDE, W
    VANDENHEEDE, JR
    BIOCHEMICAL PHARMACOLOGY, 1993, 46 (11) : 1929 - 1936
  • [22] RELATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR CONCENTRATION TO GROWTH OF HUMAN EPIDERMOID CARCINOMA A431 CELLS
    KAWAMOTO, T
    MENDELSOHN, J
    LE, A
    SATO, GH
    LAZAR, CS
    GILL, GN
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, 259 (12) : 7761 - 7766
  • [23] KINETICS AND REGULATION OF THE TYROSINE PHOSPHORYLATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN INTACT A431 CELLS
    STURANI, E
    ZIPPEL, R
    TOSCHI, L
    MORELLO, L
    COMOGLIO, PM
    ALBERGHINA, L
    MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (03) : 1345 - 1351
  • [24] EFFECT OF CARBOXYL TERMINAL TRUNCATION ON THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
    WEDEGAERTNER, PB
    GILL, GN
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 292 (01) : 273 - 280
  • [25] RESISTANCE TO PHOSPHATASE OF THIOPHOSPHORYLATED EPIDERMAL GROWTH-FACTOR RECEPTOR IN A431 MEMBRANES
    CASSEL, D
    GLASER, L
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (07): : 2231 - 2235
  • [26] INHIBITION OF EPIDERMAL GROWTH FACTOR-STIMULATED EGF RECEPTOR TYROSINE KINASE-ACTIVITY IN A431 HUMAN EPIDERMOID CARCINOMA-CELLS BY POLYAMINES
    FAALAND, CA
    LASKIN, JD
    THOMAS, TJ
    CELL GROWTH & DIFFERENTIATION, 1995, 6 (02): : 115 - 121
  • [27] EPIDERMAL GROWTH-FACTOR ENHANCES A MICROSOMAL 12-LIPOXYGENASE ACTIVITY IN A431 CELLS
    CHANG, WC
    NING, CC
    LIN, MT
    HUANG, JD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (06) : 3657 - 3666
  • [28] RAPID INCREASES IN THE TRANSGLUTAMINASE ACTIVITY OF A431 CELLS FOLLOWING TREATMENT WITH EPIDERMAL GROWTH-FACTOR
    DADABAY, CY
    PIKE, LJ
    BIOCHEMISTRY, 1987, 26 (21) : 6587 - 6591
  • [29] TRANSFORMING GROWTH-FACTOR-BETA MODULATES PHOSPHORYLATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND PROLIFERATION OF A431 CELLS
    GOLDKORN, T
    MENDELSOHN, J
    CELL GROWTH & DIFFERENTIATION, 1992, 3 (02): : 101 - 109
  • [30] BIOSYNTHESIS OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN EPIDERMOID CARCINOMA-DERIVED A431 CELLS
    CARLIN, CR
    KNOWLES, BB
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, 259 (12) : 7902 - 7908
12345