INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS

被引：121

作者：

KORUTLA, L

KUMAR, R

机构：

[1] PENN STATE UNIV,COLL MED,DEPT MED,HERSHEY,PA 17033

[2] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1224卷 / 03期

关键词：

CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KINASE ACTIVITY; A431; CELL;

D O I：

10.1016/0167-4889(94)90299-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.

引用

页码：597 / 600

页数：4

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