INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS

被引：121
|
作者：
KORUTLA, L
KUMAR, R
机构：
[1] PENN STATE UNIV,COLL MED,DEPT MED,HERSHEY,PA 17033
[2] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1224卷 / 03期
关键词：
CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KINASE ACTIVITY; A431; CELL;
D O I：
10.1016/0167-4889(94)90299-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.
引用
收藏
页码：597 / 600
页数：4
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