Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

被引：0

作者：

Sergiu P Paşca

Thomas Portmann

Irina Voineagu

Masayuki Yazawa

Aleksandr Shcheglovitov

Anca M Paşca

Branden Cord

Theo D Palmer

Sachiko Chikahisa

Seiji Nishino

Jonathan A Bernstein

Joachim Hallmayer

Daniel H Geschwind

Ricardo E Dolmetsch

机构：

[1] Stanford University School of Medicine,Department of Neurobiology

[2] David Geffen School of Medicine,Department of Neurology and Program in Neurogenetics

[3] University of California,Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery

[4] Stanford School of Medicine,Department of Psychiatry and Behavioral Science

[5] Stanford University School of Medicine,Department of Integrative Physiology

[6] Institute of Health Biosciences,Department of Pediatrics

[7] The University of Tokushima Graduate School,undefined

[8] Stanford University School of Medicine,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Timothy syndrome is a neurodevelopmental disease that includes autism-like features. Using iPS-derived neurons from individuals with Timothy syndrome, Ricardo Dolmetsch and his colleagues identify changes in cortical neuron fate and neurotransmitter expression that may begin to explain the neural mechanisms that underlie this disorder.

引用

页码：1657 / 1662

页数：5

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