Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

被引：0
|
作者：
Sergiu P Paşca
Thomas Portmann
Irina Voineagu
Masayuki Yazawa
Aleksandr Shcheglovitov
Anca M Paşca
Branden Cord
Theo D Palmer
Sachiko Chikahisa
Seiji Nishino
Jonathan A Bernstein
Joachim Hallmayer
Daniel H Geschwind
Ricardo E Dolmetsch
机构：
[1] Stanford University School of Medicine,Department of Neurobiology
[2] David Geffen School of Medicine,Department of Neurology and Program in Neurogenetics
[3] University of California,Stanford Institute for Stem Cell Biology and Regenerative Medicine and Department of Neurosurgery
[4] Stanford School of Medicine,Department of Psychiatry and Behavioral Science
[5] Stanford University School of Medicine,Department of Integrative Physiology
[6] Institute of Health Biosciences,Department of Pediatrics
[7] The University of Tokushima Graduate School,undefined
[8] Stanford University School of Medicine,undefined
来源：
Nature Medicine | 2011年 / 17卷
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中图分类号：
学科分类号：
摘要：
Timothy syndrome is a neurodevelopmental disease that includes autism-like features. Using iPS-derived neurons from individuals with Timothy syndrome, Ricardo Dolmetsch and his colleagues identify changes in cortical neuron fate and neurotransmitter expression that may begin to explain the neural mechanisms that underlie this disorder.
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页码：1657 / 1662
页数：5
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