Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone

被引：0
|
作者：
A. M. Jassem
A. H. Raheemah
W. A. Radhi
A. M. Alid
H. A. Jaber
机构：
[1] Basrah University,Department of Chemistry, College of Education for Pure Sciences
[2] Al-Mustansiriya University,Department of Chemistry, College of Science
[3] Basrah University,Department of Chemistry, Polymer Research Center
[4] Basrah University,Department of Material Science, Polymer Research Center
来源：
Russian Journal of Organic Chemistry | 2019年 / 55卷
关键词：
spiroimidazolidinone; L-valine; catalysis; diastereoselectivity; DFT quantum chemical computations; B3LYP/6-31G(; );
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.
引用
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页码：1598 / 1603
页数：5
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