SERPINB2—its regulation and interplay with aryl hydrocarbon receptor

被引：0
|
作者：
Damian Brauze
机构：
[1] Polish Academy of Sciences,Institute of Human Genetics
来源：
Journal of Applied Genetics | 2021年 / 62卷
关键词：
SERPINB2; Aryl hydrocarbon receptor; Immune response; Cancer development;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite many years of intensive investigation, real biological role of SERPINB2 is largely unknown. However, recent high throughput studies suggest its function in inflammation, influence on autoimmune disorders, and modulation of processes leading to carcinogenesis. SERPINB2 expression is acutely upregulated by many different stimuli, among others by aryl hydrocarbon receptor ligands. Mechanisms of regulation of SERPINB2 expression, involvement of the gene in processes leading to inflammation or carcinogenesis, and its interplay with aryl hydrocarbon receptor are subject of present review.
引用
收藏
页码：99 / 105
页数：6
相关论文
共 50 条
  • [41] SERPINB2, TREM2 AND DAP12 AS BIOMARKERS FOR LEPROSY
    Pouldar, D. M.
    Teles, R. M.
    Modlin, R. L.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2015, 63 (01) : 211 - 212
  • [42] Secretion of SerpinB2 from endothelial cells activated with inflammatory stimuli
    Boncela, Joanna
    Przygodzka, Patrycja
    Wyroba, Elzbieta
    Papiewska-Pajak, Izabela
    Cierniewski, Czeslaw S.
    EXPERIMENTAL CELL RESEARCH, 2013, 319 (08) : 1213 - 1219
  • [43] SERPINB2, TREM2, and DAP12 as biomarkers for leprosy
    Pouldar, Delila
    Teles, Rosane
    Modlin, Robert
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015, 72 (05) : AB33 - AB33
  • [44] The aryl hydrocarbon receptor: What is its role in the skeleton?
    Puzas, JE
    Ryan, E
    Drissi, H
    O'Keefe, RJ
    Zuscik, MJ
    Rosier, RN
    Schwarz, EM
    Gasiewicz, TA
    JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 : S222 - S223
  • [45] Low expression of SerpinB2 is associated with reduced survival in lung adenocarcinomas
    Ramnefjell, Maria
    Aamelfot, Christina
    Helgeland, Lars
    Akslen, Lars A.
    ONCOTARGET, 2017, 8 (53) : 90706 - 90718
  • [46] SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer
    Harris, N. L. E.
    Vennin, C.
    Conway, J. R. W.
    Vine, K. L.
    Pinese, M.
    Cowley, M. J.
    Shearer, R. F.
    Lucas, M. C.
    Herrmann, D.
    Allam, A. H.
    Pajic, M.
    Morton, J. P.
    Biankin, A. V.
    Ranson, M.
    Timpson, P.
    Saunders, D. N.
    ONCOGENE, 2017, 36 (30) : 4288 - 4298
  • [47] Transcriptional regulation of endothelin-1 by the aryl hydrocarbon receptor
    Zhang, N
    Lund, AK
    Walker, MK
    FASEB JOURNAL, 2006, 20 (04): : A667 - A667
  • [48] Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS
    Rothhammer, Veit
    Borucki, Davis M.
    Sanchez, Maria Isabel Garcia
    Mazzola, Maria Antonietta
    Hemond, Christopher C.
    Regev, Keren
    Paul, Anu
    Kiviakk, Pia
    Bakshi, Rohit
    Izquierdo, Guillermo
    Weiner, Howard L.
    Quintana, Francisco J.
    NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2017, 4 (04):
  • [49] New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor
    Xie, Heidi Qunhui
    Ma, Yongchao
    Fu, Hualing
    Xu, Tuan
    Luo, Yali
    Liu, Yiyun
    Chen, Yangsheng
    Xu, Li
    Xia, Yingjie
    Zhao, Bin
    JOURNAL OF NEUROCHEMISTRY, 2021, 158 (06) : 1254 - 1262
  • [50] Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor
    Flaveny, Colin A.
    Murray, Iain A.
    Perdew, Gary H.
    TOXICOLOGICAL SCIENCES, 2010, 114 (02) : 217 - 225
12345