Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

被引：0
|
作者：
Charles M Rudin
Steffen Durinck
Eric W Stawiski
John T Poirier
Zora Modrusan
David S Shames
Emily A Bergbower
Yinghui Guan
James Shin
Joseph Guillory
Celina Sanchez Rivers
Catherine K Foo
Deepali Bhatt
Jeremy Stinson
Florian Gnad
Peter M Haverty
Robert Gentleman
Subhra Chaudhuri
Vasantharajan Janakiraman
Bijay S Jaiswal
Chaitali Parikh
Wenlin Yuan
Zemin Zhang
Hartmut Koeppen
Thomas D Wu
Howard M Stern
Robert L Yauch
Kenneth E Huffman
Diego D Paskulin
Peter B Illei
Marileila Varella-Garcia
Adi F Gazdar
Frederic J de Sauvage
Richard Bourgon
John D Minna
Malcolm V Brock
Somasekar Seshagiri
机构：
[1] The Sidney Kimmel Comprehensive Cancer Center,Department of Molecular Biology
[2] Johns Hopkins University,Department of Bioinformatics and Computational Biology
[3] Genentech,Department of Oncology Biomarker Development
[4] South San Francisco,Department of Pathology
[5] California,Division of Medical Oncology
[6] USA.,undefined
[7] Genentech,undefined
[8] South San Francisco,undefined
[9] California,undefined
[10] USA.,undefined
[11] Genentech,undefined
[12] South San Francisco,undefined
[13] California,undefined
[14] USA.,undefined
[15] Genentech,undefined
[16] Hamon Center for Therapeutic Oncology Research,undefined
[17] University of Texas Southwestern Medical Center,undefined
[18] University of Colorado Cancer Center,undefined
来源：
Nature Genetics | 2012年 / 44卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sekar Seshagiri and colleagues report exome, transcriptome and copy-number alteration data in small-cell lung cancer. The authors find SOX2 amplification in 27% of samples and also identify a recurrent RFL-MYCL1 fusion.
引用
收藏
页码：1111 / 1116
页数：5
相关论文
共 50 条
  • [41] Specifically targeted gene therapy for small-cell lung cancer
    Christensen, Camilla L.
    Zandi, Roza
    Gjetting, Torben
    Cramer, Frederik
    Poulsen, Hans S.
    EXPERT REVIEW OF ANTICANCER THERAPY, 2009, 9 (04) : 437 - 452
  • [42] SOX2 Promotes Radioresistance in Non-small Cell Lung Cancer by Regulating Tumor Cells Dedifferentiation
    Wang, Shennan
    Li, Zhou
    Li, Piao
    Li, Lingling
    Liu, Yu
    Feng, Yanqi
    Li, Ruichao
    Xia, Shu
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2023, 20 (06): : 781 - 796
  • [43] Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer
    Schaal, Courtney M.
    Bora-Singhal, Namrata
    Kumar, Durairaj Mohan
    Chellappan, Srikumar P.
    MOLECULAR CANCER, 2018, 17
  • [44] Small-cell lung cancer from the peripheral lung is frequently accompanied by emphysema and interstitial lung disease in the background
    Ikematsu, Yuki
    Izumi, Miiru
    Takayama, Koichi
    Kumazoe, Hiroyuki
    Wakamatsu, Kentaro
    Kawasaki, Masayuki
    THORACIC CANCER, 2022, 13 (18) : 2616 - 2623
  • [45] Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer
    Courtney M Schaal
    Namrata Bora-Singhal
    Durairaj Mohan Kumar
    Srikumar P Chellappan
    Molecular Cancer, 17
  • [46] Distinct transcriptional programs of SOX2 in different types of small cell lung cancers
    Tenjin, Yuki
    Matsuura, Kumi
    Kudoh, Shinji
    Usuki, Shingo
    Yamada, Tatsuya
    Matsuo, Akira
    Sato, Younosuke
    Saito, Haruki
    Fujino, Kosuke
    Wakimoto, Joeji
    Ichimura, Takaya
    Kohrogi, Hirotsugu
    Sakagami, Takuro
    Niwa, Hitoshi
    Ito, Takaaki
    LABORATORY INVESTIGATION, 2020, 100 (12) : 1575 - 1588
  • [47] Bioinformatic analysis identifies polo-like kinase as a therapeutic target in small-cell lung cancer
    Wildey, Gary
    Chen, Yanwen
    Lent, Ian
    Stetson, Lindsay
    Pink, John
    Barnholtz-Sloan, Jill
    Dowlati, Afshin
    CANCER RESEARCH, 2014, 74 (19)
  • [48] ALK Rearrangements in Non-Small Cell Lung Cancer: Comprehensive Integration of Genomic, Gene Expression and Protein Analysis
    Mattsson, Johanna S. M.
    Svensson, Maria A.
    Hallstrom, Bjorn
    Koyi, Hirsh
    Branden, Eva
    Brunnstrom, Hans
    Edlund, Karolina
    Ekman, Simon
    La Fleur, Linnea
    Grinberg, Marianna
    Rahnenfuehrer, Joerg
    Jirstrom, Karin
    Ponten, Fredrik
    Karlsson, Mats G.
    Karlsson, Christina
    Helenius, Gisela
    Uhlen, Mathias
    Botling, Johan
    Micke, Patrick
    JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S298 - S298
  • [49] Mistletoe lectin inhibits growth of Myc-amplified small-cell lung cancer
    Shatat, Mohammad A. A.
    Gauthier, Betsy
    Yoon, Suzy
    Yuan, Eric
    Yang, Peiying
    Narla, Goutham
    Dowlati, Afshin
    Lee, Richard T. T.
    CANCER MEDICINE, 2023, 12 (07): : 8378 - 8387
  • [50] Detection of amplified genomic sequences in human small-cell lung carcinoma cells by arbitrarily primed-PCR genomic fingerprinting
    Okazaki, T
    Takita, J
    Kohno, T
    Handa, H
    Yokota, J
    HUMAN GENETICS, 1996, 98 (03) : 253 - 258
12345