Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

被引：0
|
作者：
Charles M Rudin
Steffen Durinck
Eric W Stawiski
John T Poirier
Zora Modrusan
David S Shames
Emily A Bergbower
Yinghui Guan
James Shin
Joseph Guillory
Celina Sanchez Rivers
Catherine K Foo
Deepali Bhatt
Jeremy Stinson
Florian Gnad
Peter M Haverty
Robert Gentleman
Subhra Chaudhuri
Vasantharajan Janakiraman
Bijay S Jaiswal
Chaitali Parikh
Wenlin Yuan
Zemin Zhang
Hartmut Koeppen
Thomas D Wu
Howard M Stern
Robert L Yauch
Kenneth E Huffman
Diego D Paskulin
Peter B Illei
Marileila Varella-Garcia
Adi F Gazdar
Frederic J de Sauvage
Richard Bourgon
John D Minna
Malcolm V Brock
Somasekar Seshagiri
机构：
[1] The Sidney Kimmel Comprehensive Cancer Center,Department of Molecular Biology
[2] Johns Hopkins University,Department of Bioinformatics and Computational Biology
[3] Genentech,Department of Oncology Biomarker Development
[4] South San Francisco,Department of Pathology
[5] California,Division of Medical Oncology
[6] USA.,undefined
[7] Genentech,undefined
[8] South San Francisco,undefined
[9] California,undefined
[10] USA.,undefined
[11] Genentech,undefined
[12] South San Francisco,undefined
[13] California,undefined
[14] USA.,undefined
[15] Genentech,undefined
[16] Hamon Center for Therapeutic Oncology Research,undefined
[17] University of Texas Southwestern Medical Center,undefined
[18] University of Colorado Cancer Center,undefined
来源：
Nature Genetics | 2012年 / 44卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sekar Seshagiri and colleagues report exome, transcriptome and copy-number alteration data in small-cell lung cancer. The authors find SOX2 amplification in 27% of samples and also identify a recurrent RFL-MYCL1 fusion.
引用
收藏
页码：1111 / 1116
页数：5
相关论文
共 50 条
  • [21] Comprehensive genomic profiles of small cell lung cancer
    Julie George
    Jing Shan Lim
    Se Jin Jang
    Yupeng Cun
    Luka Ozretić
    Gu Kong
    Frauke Leenders
    Xin Lu
    Lynnette Fernández-Cuesta
    Graziella Bosco
    Christian Müller
    Ilona Dahmen
    Nadine S. Jahchan
    Kwon-Sik Park
    Dian Yang
    Anthony N. Karnezis
    Dedeepya Vaka
    Angela Torres
    Maia Segura Wang
    Jan O. Korbel
    Roopika Menon
    Sung-Min Chun
    Deokhoon Kim
    Matt Wilkerson
    Neil Hayes
    David Engelmann
    Brigitte Pützer
    Marc Bos
    Sebastian Michels
    Ignacija Vlasic
    Danila Seidel
    Berit Pinther
    Philipp Schaub
    Christian Becker
    Janine Altmüller
    Jun Yokota
    Takashi Kohno
    Reika Iwakawa
    Koji Tsuta
    Masayuki Noguchi
    Thomas Muley
    Hans Hoffmann
    Philipp A. Schnabel
    Iver Petersen
    Yuan Chen
    Alex Soltermann
    Verena Tischler
    Chang-min Choi
    Yong-Hee Kim
    Pierre P. Massion
    Nature, 2015, 524 : 47 - 53
  • [22] Comprehensive genomic characterization of small cell lung cancer
    George, Julie
    Lim, Jing Shan
    Peifer, Martin
    Sage, Julien
    Thomas, Roman
    CANCER RESEARCH, 2015, 75
  • [23] Comprehensive genomic profiles of small cell lung cancer
    George, Julie
    Lim, Jing Shan
    Jang, Se Jin
    Cun, Yupeng
    Ozretic, Luka
    Kong, Gu
    Leenders, Frauke
    Lu, Xin
    Fernandez-Cuesta, Lynnette
    Bosco, Graziella
    Mueller, Christian
    Dahmen, Ilona
    Jahchan, Nadine S.
    Park, Kwon-Sik
    Yang, Dian
    Karnezis, Anthony N.
    Vaka, Dedeepya
    Torres, Angela
    Wang, Maia Segura
    Korbel, Jan O.
    Menon, Roopika
    Chun, Sung-Min
    Kim, Deokhoon
    Wilkerson, Matt
    Hayes, Neil
    Engelmann, David
    Puetzer, Brigitte
    Bos, Marc
    Michels, Sebastian
    Vlasic, Ignacija
    Seidel, Danila
    Pinther, Berit
    Schaub, Philipp
    Becker, Christian
    Altmueller, Janine
    Yokota, Jun
    Kohno, Takashi
    Iwakawa, Reika
    Tsuta, Koji
    Noguchi, Masayuki
    Muley, Thomas
    Hoffmann, Hans
    Schnabel, Philipp A.
    Petersen, Iver
    Chen, Yuan
    Soltermann, Alex
    Tischler, Verena
    Choi, Chang-min
    Kim, Yong-Hee
    Massion, Pierre P.
    NATURE, 2015, 524 (7563) : 47 - 53
  • [24] Comprehensive Genomic Profiling Differentiates Metachronous Primary Small-Cell Lung Cancer From Late Recurrence
    Gao, Xin
    VanderLaan, Paul A.
    Bailey, Alexandra S.
    Costa, Daniel B.
    CLINICAL LUNG CANCER, 2016, 17 (05) : E169 - E172
  • [25] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
    Adam J Bass
    Hideo Watanabe
    Craig H Mermel
    Soyoung Yu
    Sven Perner
    Roel G Verhaak
    So Young Kim
    Leslie Wardwell
    Pablo Tamayo
    Irit Gat-Viks
    Alex H Ramos
    Michele S Woo
    Barbara A Weir
    Gad Getz
    Rameen Beroukhim
    Michael O'Kelly
    Amit Dutt
    Orit Rozenblatt-Rosen
    Piotr Dziunycz
    Justin Komisarof
    Lucian R Chirieac
    Christopher J LaFargue
    Veit Scheble
    Theresia Wilbertz
    Changqing Ma
    Shilpa Rao
    Hiroshi Nakagawa
    Douglas B Stairs
    Lin Lin
    Thomas J Giordano
    Patrick Wagner
    John D Minna
    Adi F Gazdar
    Chang Qi Zhu
    Marcia S Brose
    Ivan Cecconello
    Ulysses Ribeiro Jr
    Suely K Marie
    Olav Dahl
    Ramesh A Shivdasani
    Ming-Sound Tsao
    Mark A Rubin
    Kwok K Wong
    Aviv Regev
    William C Hahn
    David G Beer
    Anil K Rustgi
    Matthew Meyerson
    Nature Genetics, 2009, 41 : 1238 - 1242
  • [26] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
    Bass, Adam J.
    Watanabe, Hideo
    Mermel, Craig H.
    Yu, Soyoung
    Perner, Sven
    Verhaak, Roel G.
    Kim, So Young
    Wardwell, Leslie
    Tamayo, Pablo
    Gat-Viks, Irit
    Ramos, Alex H.
    Woo, Michele S.
    Weir, Barbara A.
    Getz, Gad
    Beroukhim, Rameen
    O'Kelly, Michael
    Dutt, Amit
    Rozenblatt-Rosen, Orit
    Dziunycz, Piotr
    Komisarof, Justin
    Chirieac, Lucian R.
    LaFargue, Christopher J.
    Scheble, Veit
    Wilbertz, Theresia
    Ma, Changqing
    Rao, Shilpa
    Nakagawa, Hiroshi
    Stairs, Douglas B.
    Lin, Lin
    Giordano, Thomas J.
    Wagner, Patrick
    Minna, John D.
    Gazdar, Adi F.
    Zhu, Chang Qi
    Brose, Marcia S.
    Cecconello, Ivan
    Ribeiro, Ulysses, Jr.
    Marie, Suely K.
    Dahl, Olav
    Shivdasani, Ramesh A.
    Tsao, Ming-Sound
    Rubin, Mark A.
    Wong, Kwok K.
    Regev, Aviv
    Hahn, William C.
    Beer, David G.
    Rustgi, Anil K.
    Meyerson, Matthew
    NATURE GENETICS, 2009, 41 (11) : 1238 - U105
  • [27] The cancer stemness inhibitor napabucasin suppresses small cell lung cancer growth through SOX2 expression
    Li, Jhy-Ming
    Hsu, Ping-Chih
    Kuan, Feng-Che
    Shi, Chung-Sheng
    Yang, Cheng-Ta
    AMERICAN JOURNAL OF CANCER RESEARCH, 2022, 12 (10): : 4637 - +
  • [28] Genomic Profiling of Extensive Stage Small-Cell Lung Cancer Patients Identifies Molecular Factors Associated with Survival
    Canale, Matteo
    Urbini, Milena
    Petracci, Elisabetta
    Angeli, Davide
    Tedaldi, Gianluca
    Priano, Ilaria
    Cravero, Paola
    Flospergher, Michele
    Andrikou, Kalliopi
    Bennati, Chiara
    Tassinari, Davide
    Dubini, Alessandra
    Rossi, Giulio
    Panzacchi, Riccardo
    Valli, Mirca
    Bronte, Giuseppe
    Crino, Lucio
    Delmonte, Angelo
    Ulivi, Paola
    LUNG CANCER-TARGETS AND THERAPY, 2025, 16 : 11 - 23
  • [29] SOX2 Amplification Is a Frequent Event in Squamous Cell Lung Cancer
    Wilbertz, T.
    Wagner, P.
    Stiedl, A. C.
    Petersen, K.
    Scheble, V.
    Moch, H.
    Altorki, N. K.
    Soltermann, A.
    Perner, S.
    LABORATORY INVESTIGATION, 2010, 90 : 415A - 415A
  • [30] SOX2 Amplification Is a Frequent Event in Squamous Cell Lung Cancer
    Wilbertz, T.
    Wagner, P.
    Stiedl, A. C.
    Petersen, K.
    Scheble, V.
    Moch, H.
    Altorki, N. K.
    Soltermann, A.
    Perner, S.
    MODERN PATHOLOGY, 2010, 23 : 415A - 415A
12345