Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

被引：0
|
作者：
Charles M Rudin
Steffen Durinck
Eric W Stawiski
John T Poirier
Zora Modrusan
David S Shames
Emily A Bergbower
Yinghui Guan
James Shin
Joseph Guillory
Celina Sanchez Rivers
Catherine K Foo
Deepali Bhatt
Jeremy Stinson
Florian Gnad
Peter M Haverty
Robert Gentleman
Subhra Chaudhuri
Vasantharajan Janakiraman
Bijay S Jaiswal
Chaitali Parikh
Wenlin Yuan
Zemin Zhang
Hartmut Koeppen
Thomas D Wu
Howard M Stern
Robert L Yauch
Kenneth E Huffman
Diego D Paskulin
Peter B Illei
Marileila Varella-Garcia
Adi F Gazdar
Frederic J de Sauvage
Richard Bourgon
John D Minna
Malcolm V Brock
Somasekar Seshagiri
机构：
[1] The Sidney Kimmel Comprehensive Cancer Center,Department of Molecular Biology
[2] Johns Hopkins University,Department of Bioinformatics and Computational Biology
[3] Genentech,Department of Oncology Biomarker Development
[4] South San Francisco,Department of Pathology
[5] California,Division of Medical Oncology
[6] USA.,undefined
[7] Genentech,undefined
[8] South San Francisco,undefined
[9] California,undefined
[10] USA.,undefined
[11] Genentech,undefined
[12] South San Francisco,undefined
[13] California,undefined
[14] USA.,undefined
[15] Genentech,undefined
[16] Hamon Center for Therapeutic Oncology Research,undefined
[17] University of Texas Southwestern Medical Center,undefined
[18] University of Colorado Cancer Center,undefined
来源：
Nature Genetics | 2012年 / 44卷
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学科分类号：
摘要：
Sekar Seshagiri and colleagues report exome, transcriptome and copy-number alteration data in small-cell lung cancer. The authors find SOX2 amplification in 27% of samples and also identify a recurrent RFL-MYCL1 fusion.
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页码：1111 / 1116
页数：5
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