Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

被引：0
|
作者：
Yi-ping Zhu
Kun Xiao
Hai-ping Yu
Lan-ping Ma
Bing Xiong
Hai-yan Zhang
Xin Wang
Jing-ya Li
Jia Li
Jing-kang Shen
机构：
[1] The State Key Laboratory of Drug Research,
[2] Shanghai Institute of Materia Medica,undefined
[3] Chinese Academy of Sciences,undefined
[4] The National Center for Drug Screening,undefined
来源：
Acta Pharmacologica Sinica | 2009年 / 30卷
关键词：
aspartyl protease β-secretase; hydroxyethylene; solid phase; biological evaluation; molecular modeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：259 / 269
页数：10
相关论文
共 50 条
  • [1] Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids
    Zhu, Yi-ping
    Xiao, Kun
    Yu, Hai-ping
    Ma, Lan-ping
    Xiong, Bing
    Zhang, Hai-yan
    Wang, Xin
    Li, Jing-ya
    Li, Jia
    Shen, Jing-kang
    ACTA PHARMACOLOGICA SINICA, 2009, 30 (02) : 259 - 269
  • [2] Discovery of oxadiazoyl tertiary carbinamine inhibitors of β-secretase (BACE-1)
    Rajapakse, Hemaka A.
    Nantermet, Philippe G.
    Selnick, Harold G.
    Munshi, Sanjeev
    McGaughey, Georgia B.
    Lindsley, Stacey R.
    Young, Mary Beth
    Lai, Ming-Tain
    Espeseth, Amy S.
    Shi, Xiao-Ping
    Colussi, Dennis
    Pietrak, Beth
    Crouthamel, Ming-Chih
    Tugusheva, Katherine
    Huang, Qian
    Xu, Min
    Simon, Adam J.
    Kuo, Lawrence
    Hazuda, Daria J.
    Graham, Samuel
    Vacca, Joseph P.
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (25) : 7270 - 7273
  • [3] Design and Synthesis of Potent and Selective BACE-1 Inhibitors
    Bjorklund, Catarina
    Oscarson, Stefan
    Benkestock, Kurt
    Borkakoti, Neera
    Jansson, Katarina
    Lindberg, Jimmy
    Vrang, Lotta
    Hallberg, Anders
    Rosenquist, Asa
    Samuelsson, Bertil
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (04) : 1458 - 1464
  • [4] MEDI 513-Discovery of potent macrocyclic BACE-1 inhibitors
    Li, Guoqing
    Huang, Ying
    Stamford, Andrew W.
    Greenlee, William J.
    Kennedy, Matthew
    Chen, Xia
    Kuvelkar, Reshma
    Strickland, Corey
    Voigt, Johannes
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [5] MEDI 511-Discovery of potent pyrrolidine BACE-1 inhibitors
    Iserloh, Ulrich
    Pan, Jianping
    Buevich, Alex
    Chen, Xia
    Cumming, Jared
    Favreau, Len
    Greenlee, William
    Huang, Ying
    Kennedy, Matthew
    Kuvelkar, Reshma
    McHugh, Nansie
    Li, Guoqing
    Parker, Eric M.
    Strickland, Corey
    Stamford, Andrew
    Tucker, Greg
    Voigt, Johannes
    Wang, Lingyan
    Wu, Yusheng
    Zhang, Qi
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [6] MEDI 510-Discovery of highly potent piperazine BACE-1 inhibitors
    Huang, Ying
    Chen, Xia
    Greenlee, William
    Kennedy, Matthew
    Kuvelkar, Reshma
    Li, Guoqing
    Parker, Eric M.
    Stamford, Andrew
    Strickland, Corey
    Voigt, Johannes
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [7] Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
    Veenstra, Siem Jakob
    Rueeger, Heinrich
    Voegtle, Markus
    Lueoend, Rainer
    Holzer, Philipp
    Hurth, Konstanze
    Tintelnot-Blomley, Marina
    Frederiksen, Mathias
    Rondeau, Jean-Michel
    Jacobson, Laura
    Staufenbiel, Matthias
    Neumann, Ulf
    Machauer, Rainer
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (12) : 2195 - 2200
  • [8] Structure-guided design of β-secretase (BACE-1) inhibitors
    McGaughey, Georgia B.
    Holloway, M. Katharine
    EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (08) : 1129 - 1138
  • [9] Macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors with activity in vivo
    Machauer, Rainer
    Laumen, Kurt
    Veenstra, Siem
    Rondeau, Jean-Michel
    Tintelnot-Blomley, Marina
    Betschart, Claudia
    Jaton, Anne-Lise
    Desrayaud, Sandrine
    Staufenbiel, Matthias
    Rabe, Sabine
    Paganetti, Paolo
    Neumann, Ulf
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (05) : 1366 - 1370
  • [10] Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors
    Machauer, Rainer
    Veenstra, Siem
    Rondeau, Jean-Michel
    Tintelnot-Blomley, Marina
    Betschart, Claudia
    Neumann, Ulf
    Paganetti, Paolo
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (05) : 1361 - 1365
12345