MEDI 513-Discovery of potent macrocyclic BACE-1 inhibitors

被引：0
|
作者：
Li, Guoqing
Huang, Ying
Stamford, Andrew W. [1 ]
Greenlee, William J. [2 ]
Kennedy, Matthew
Chen, Xia
Kuvelkar, Reshma
Strickland, Corey
Voigt, Johannes
机构：
[1] Schering Plough Res Inst, CV CNS Chem Res, Kenilworth, NJ 07033 USA
[2] Schering Plough Corp, Chem Res, Kenilworth, NJ 07033 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 232卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
513-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [1] MEDI 511-Discovery of potent pyrrolidine BACE-1 inhibitors
    Iserloh, Ulrich
    Pan, Jianping
    Buevich, Alex
    Chen, Xia
    Cumming, Jared
    Favreau, Len
    Greenlee, William
    Huang, Ying
    Kennedy, Matthew
    Kuvelkar, Reshma
    McHugh, Nansie
    Li, Guoqing
    Parker, Eric M.
    Strickland, Corey
    Stamford, Andrew
    Tucker, Greg
    Voigt, Johannes
    Wang, Lingyan
    Wu, Yusheng
    Zhang, Qi
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [2] MEDI 510-Discovery of highly potent piperazine BACE-1 inhibitors
    Huang, Ying
    Chen, Xia
    Greenlee, William
    Kennedy, Matthew
    Kuvelkar, Reshma
    Li, Guoqing
    Parker, Eric M.
    Stamford, Andrew
    Strickland, Corey
    Voigt, Johannes
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [3] MEDI 186-Discovery and optimization of acyl guanidines as novel BACE-1 inhibitors
    Gerritz, Samuel W.
    Shi, Shuhao
    Zhai, Weixu
    Zhu, Shirong
    Thompson, Lorin A.
    Toyn, Jeremy H.
    Meredith, Jere E.
    Good, Andrew C.
    Muckelbauer, Jodi K.
    Camac, Daniel M.
    Dodd, Dharmpal S.
    Cook, Lynda S.
    Padmanabha, Ramesh
    Albright, Charles F.
    Sofia, Michael J.
    Poss, Michael A.
    Macor, John E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [4] Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors
    Veenstra, Siem Jakob
    Rueeger, Heinrich
    Voegtle, Markus
    Lueoend, Rainer
    Holzer, Philipp
    Hurth, Konstanze
    Tintelnot-Blomley, Marina
    Frederiksen, Mathias
    Rondeau, Jean-Michel
    Jacobson, Laura
    Staufenbiel, Matthias
    Neumann, Ulf
    Machauer, Rainer
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (12) : 2195 - 2200
  • [5] Design and discovery of macrocyclic diaminopropanes as potent inhibitors of BACE1
    Marcin, Lawrence R.
    Thompson, Lorin A.
    Higgins, Mendi A.
    Shi, JianLiang
    Boy, Kenneth M.
    Olson, Richard E.
    Good, Andrew C.
    Burton, Catherine R.
    Barten, Donna M.
    Muckelbauer, Jodi K.
    Calambur, Deepa
    Camac, Daniel M.
    Chang, ChiehYing
    Toyn, Jeremy H.
    Lentz, Kimberley A.
    Grace, James E.
    Herbst, Grace John J.
    Marino, Anthony M.
    Meredith, Jere E.
    Albright, Charlie F.
    Macor, John E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [6] Macrocyclic statine-based inhibitors of BACE-1
    Barazza, Alessandra
    Goetz, Marion
    Cadamuro, Sergio A.
    Goettig, Peter
    Willem, Michael
    Steuber, Holger
    Kohler, Tanja
    Jestel, Anja
    Reinemer, Peter
    Renner, Christian
    Bode, Wolfram
    Moroder, Luis
    CHEMBIOCHEM, 2007, 8 (17) : 2078 - 2091
  • [7] MEDI 509-Discovery and development of novel BACE-1 inhibitors: Substituted piperidine analogs
    Wu, Yusheng
    Stamford, Andrew
    Cumming, Jared
    Iserloh, Ulrich
    Greenlee, William
    Kennedy, Matthew
    Chen, Xia
    Kuvelkar, Reshma
    McHugh, Nansie
    Voigt, Johannes
    Strickland, Corey
    Favreau, Leonard
    Li, Cheng
    Liu, TongTong
    Chan, Tze-Ming
    Osterman, Rebecca
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [8] MEDI 296-Pyrrolidines as conformationally constrained diaminopropanes: A versatile scaffold for potent inhibitors of BACE-1
    Guernon, Jason M.
    Thompson, Lorin A., III
    Macor, John E.
    Tebben, Andrew J.
    Good, Andrew
    Burton, Catherine R.
    Barten, Donna M.
    Marcinkeviciene, Jovita
    Toyn, Jeremy H.
    Albright, Charlie
    Muckelbauer, Jodi K.
    Camac, Daniel
    Zvyaga, Tatyana
    Grace, James
    Lentz, Kimberly
    Boy, Kenneth M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [9] Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids
    Zhu, Yi-ping
    Xiao, Kun
    Yu, Hai-ping
    Ma, Lan-ping
    Xiong, Bing
    Zhang, Hai-yan
    Wang, Xin
    Li, Jing-ya
    Li, Jia
    Shen, Jing-kang
    ACTA PHARMACOLOGICA SINICA, 2009, 30 (02) : 259 - 269
  • [10] Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids
    Yi-ping Zhu
    Kun Xiao
    Hai-ping Yu
    Lan-ping Ma
    Bing Xiong
    Hai-yan Zhang
    Xin Wang
    Jing-ya Li
    Jia Li
    Jing-kang Shen
    Acta Pharmacologica Sinica, 2009, 30 : 259 - 269
12345