MEDI 509-Discovery and development of novel BACE-1 inhibitors: Substituted piperidine analogs

被引:0
|
作者
Wu, Yusheng [1 ]
Stamford, Andrew [1 ]
Cumming, Jared [1 ]
Iserloh, Ulrich [1 ]
Greenlee, William [1 ]
Kennedy, Matthew [1 ]
Chen, Xia [1 ]
Kuvelkar, Reshma [1 ]
McHugh, Nansie [1 ]
Voigt, Johannes [1 ]
Strickland, Corey [1 ]
Favreau, Leonard [1 ]
Li, Cheng [1 ]
Liu, TongTong [1 ]
Chan, Tze-Ming [1 ]
Osterman, Rebecca [1 ]
机构
[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
509-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] MEDI 186-Discovery and optimization of acyl guanidines as novel BACE-1 inhibitors
    Gerritz, Samuel W.
    Shi, Shuhao
    Zhai, Weixu
    Zhu, Shirong
    Thompson, Lorin A.
    Toyn, Jeremy H.
    Meredith, Jere E.
    Good, Andrew C.
    Muckelbauer, Jodi K.
    Camac, Daniel M.
    Dodd, Dharmpal S.
    Cook, Lynda S.
    Padmanabha, Ramesh
    Albright, Charles F.
    Sofia, Michael J.
    Poss, Michael A.
    Macor, John E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [2] MEDI 513-Discovery of potent macrocyclic BACE-1 inhibitors
    Li, Guoqing
    Huang, Ying
    Stamford, Andrew W.
    Greenlee, William J.
    Kennedy, Matthew
    Chen, Xia
    Kuvelkar, Reshma
    Strickland, Corey
    Voigt, Johannes
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [3] MEDI 511-Discovery of potent pyrrolidine BACE-1 inhibitors
    Iserloh, Ulrich
    Pan, Jianping
    Buevich, Alex
    Chen, Xia
    Cumming, Jared
    Favreau, Len
    Greenlee, William
    Huang, Ying
    Kennedy, Matthew
    Kuvelkar, Reshma
    McHugh, Nansie
    Li, Guoqing
    Parker, Eric M.
    Strickland, Corey
    Stamford, Andrew
    Tucker, Greg
    Voigt, Johannes
    Wang, Lingyan
    Wu, Yusheng
    Zhang, Qi
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [4] MEDI 510-Discovery of highly potent piperazine BACE-1 inhibitors
    Huang, Ying
    Chen, Xia
    Greenlee, William
    Kennedy, Matthew
    Kuvelkar, Reshma
    Li, Guoqing
    Parker, Eric M.
    Stamford, Andrew
    Strickland, Corey
    Voigt, Johannes
    Zhang, Lili
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [5] Design and development of BACE-1 inhibitors
    Cumming, JN
    Iserloh, U
    Kennedy, ME
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2004, 7 (04) : 536 - 556
  • [6] Computational Methods in the Discovery and Design of BACE-1 Inhibitors
    Kacker, P.
    Bottegoni, G.
    Cavalli, A.
    CURRENT MEDICINAL CHEMISTRY, 2012, 19 (36) : 6095 - 6111
  • [7] Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
    Iserloh, U.
    Wu, Y.
    Cumming, J. N.
    Pan, J.
    Wang, L. Y.
    Stamford, A. W.
    Kennedy, M. E.
    Kuvelkar, R.
    Chen, X.
    Parker, E. M.
    Strickland, C.
    Voigt, J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (01) : 414 - 417
  • [8] MEDI 65-Synthesis and SAR of acyl guanidines as BACE-1 inhibitors
    Zhang, Yunhui
    Wu, Yong-Jin
    He, Huan
    Thompson, Lonn
    Shi, Joe
    Zhu, Shirong
    Gerritz, Samuel
    Good, Andrew
    Muckelbauer, Jodi
    Burton, Catherine R.
    Toyn, Jeremy H.
    Albright, Charlie F.
    Tebben, Andy
    Macor, John
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [9] Discovery of oxadiazoyl tertiary carbinamine inhibitors of β-secretase (BACE-1)
    Rajapakse, Hemaka A.
    Nantermet, Philippe G.
    Selnick, Harold G.
    Munshi, Sanjeev
    McGaughey, Georgia B.
    Lindsley, Stacey R.
    Young, Mary Beth
    Lai, Ming-Tain
    Espeseth, Amy S.
    Shi, Xiao-Ping
    Colussi, Dennis
    Pietrak, Beth
    Crouthamel, Ming-Chih
    Tugusheva, Katherine
    Huang, Qian
    Xu, Min
    Simon, Adam J.
    Kuo, Lawrence
    Hazuda, Daria J.
    Graham, Samuel
    Vacca, Joseph P.
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (25) : 7270 - 7273
  • [10] Structure based design of novel hydroxyethylamine BACE-1 inhibitors
    Rueeger, Heinrich
    Frederiksen, Mathias
    Lueoend, Rainer
    McCarthy, Clive
    Moebitz, Henrik
    Neumann, Ulf
    Rondeau, Jean-Michel
    Roy, Bernard
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238