Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

被引：0
|
作者：
Tetsu Tsubogo
Hidekazu Oyamada
Shū Kobayashi
机构：
[1] School of Science,Department of Chemistry and Green & Sustainable Chemistry Social Cooperation Laboratory
[2] The University of Tokyo,undefined
来源：
Nature | 2015年 / 520卷
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D O I：
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学科分类号：
摘要：
The continuous-flow synthesis of both enantiomers of a complex molecule, the anti-inflammatory drug rolipram, is described, using only columns packed with achiral and chiral heterogeneous catalysts, thus enabling batch processing to be avoided.
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页码：329 / 332
页数：3
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