Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

被引：0

作者：

Tetsu Tsubogo

Hidekazu Oyamada

Shū Kobayashi

机构：

[1] School of Science,Department of Chemistry and Green & Sustainable Chemistry Social Cooperation Laboratory

[2] The University of Tokyo,undefined

来源：

Nature | 2015年 / 520卷

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D O I：

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学科分类号：

摘要：

The continuous-flow synthesis of both enantiomers of a complex molecule, the anti-inflammatory drug rolipram, is described, using only columns packed with achiral and chiral heterogeneous catalysts, thus enabling batch processing to be avoided.

引用

页码：329 / 332

页数：3

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