Continuous Flow Science in an Undergraduate Teaching Laboratory: Synthesis of Ethylene Glycol Diacetate Using Heterogeneous Catalysts in Continuous Flow

被引：6

作者：

Sun, Maolin ^{[1
]}

Liang, Chaoming ^{[1
]}

Shen, Xinyuan ^{[1
]}

Li, Jianchang ^{[1
]}

Cheng, Ruihua ^{[2
]}

Ye, Jinxing ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

来源：

JOURNAL OF CHEMICAL EDUCATION | 2021年 / 98卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Second-Year Undergraduate; Organic Chemistry; Laboratory Instruction; Esters; Upper-Division Undergraduate; Green Chemistry; Synthesis; Catalysis;

D O I：

10.1021/acs.jchemed.0c01226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The laboratory experiment regarding esterification of ethylene glycol with acetic acid to ethylene glycol diacetate using resin catalysts in a continuous flow was designed to carry out the reaction in a flow through an inquiry-guided approach. Incorporating the burgeoning field of continuous flow chemistry into the educational infrastructure, the experiment showed the practical application of heterogeneous catalysts in continuous flow synthesis. In a discussion of the importance of continuous flow chemistry and heterogeneous catalysis, students were encouraged to seek effective, sustainable, and environmentally friendly approaches to synthesize compounds.

引用

页码：572 / 576

页数：5

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