user

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

被引：0
|
作者：
Tetsu Tsubogo
Hidekazu Oyamada
Shū Kobayashi
机构：
[1] School of Science,Department of Chemistry and Green & Sustainable Chemistry Social Cooperation Laboratory
[2] The University of Tokyo,undefined
来源：
Nature | 2015年 / 520卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The continuous-flow synthesis of both enantiomers of a complex molecule, the anti-inflammatory drug rolipram, is described, using only columns packed with achiral and chiral heterogeneous catalysts, thus enabling batch processing to be avoided.
引用
收藏
页码：329 / 332
页数：3
相关论文
共 50 条
  • [1] Multistep continuous-flow synthesis of (R) - and (S) -rolipram using heterogeneous catalysts
    Tsubogo, Tetsu
    Oyamada, Hidekazu
    Kobayashi, Shu
    NATURE, 2015, 520 (7547) : 329 - 332
  • [2] Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles
    Loevei, Klara
    Greiner, Istvan
    Eles, Janos
    Szigetvari, Aron
    Dekany, Miklos
    Levai, Sandor
    Novak, Zoltan
    Turos, Gyoergy Istvan
    JOURNAL OF FLOW CHEMISTRY, 2015, 5 (02) : 74 - 81
  • [3] Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles
    Klára Lövei
    István Greiner
    János Éles
    Áron Szigetvári
    Miklós Dékány
    Sándor Lévai
    Zoltán Novák
    György István Túrós
    Journal of Flow Chemistry, 2015, 5 : 74 - 81
  • [4] Continuous-Flow Synthesis of (R)-Tamsulosin Utilizing Sequential Heterogeneous Catalysis
    Saito, Yuki
    Nishizawa, Ken
    Laroche, Benjamin
    Ishitani, Haruro
    Kobayashi, Shu
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (13)
  • [5] Synthesis of Nitro-Containing Compounds through Multistep Continuous Flow with Heterogeneous Catalysts
    Ishitani, Haruro
    Saito, Yuki
    Tsubogo, Tetsu
    Kobayashi, Shu
    ORGANIC LETTERS, 2016, 18 (06) : 1346 - 1349
  • [6] Multistep continuous-flow microchemical synthesis involving multiple reactions and separations
    Sahoo, Hemantkumar R.
    Kralj, Jason G.
    Jensen, Klavs F.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (30) : 5704 - 5708
  • [7] Continuous-Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
    Saito, Yuki
    Kobayashi, Shu
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 63 (01)
  • [8] Continuous-Flow Synthesis of β-Ketoesters and Successive Reactions in One-Flow using Heterogeneous Catalysis
    Kandasamy, Mohanraj
    Ishitani, Haruro
    Kobayashi, Shu
    ADVANCED SYNTHESIS & CATALYSIS, 2022, 364 (19) : 3389 - 3395
  • [9] A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands
    Petersen, Trine P.
    Ritzen, Andreas
    Ulven, Trond
    ORGANIC LETTERS, 2009, 11 (22) : 5134 - 5137
  • [10] Continuous-flow synthesis using a column reactor packed with heterogeneous catalysts: A convenient production of nitroolefins by using amino-functionalized silicagel
    Ishitani, Haruro
    Furiya, Yuichi
    Kobayashi, Shu
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (23) : 6229 - 6232
12345