Preparation and in Vitro/in Vivo Evaluation of Insulin-Loaded Poly(Acryloyl-Hydroxyethyl Starch)-PLGA Composite Microspheres

被引：0
|
作者：
Ge Jiang
Wei Qiu
Patrick P. DeLuca
机构：
[1] University of Kentucky ,Pharmaceutical Sciences
[2] College of Pharmacy,undefined
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
PLGA; hydroxyethyl starch; microsphere; insulin; controlled release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this study was to develop and evaluate a novel composite microsphere delivery system composed of poly(D,L-lactide-co-glycolide) (PLGA) and poly(acryloyl hydroxyethyl starch) (acryloyl derivatized HES; AcHES) hydrogel using bovine insulin as a model therapeutic protein.
引用
收藏
页码：452 / 459
页数：7
相关论文
共 50 条
  • [41] In vitro and in vivo evaluation of calcium phosphate composite scaffolds containing BMP-VEGF loaded PLGA microspheres for the treatment of avascular necrosis of the femoral head
    Zhang, Hao-Xuan
    Zhang, Xiu-Ping
    Xiao, Gui-Yong
    Hou, Yong
    Cheng, Lei
    Si, Meng
    Wang, Shuai-Shuai
    Li, Yu-Hua
    Nie, Lin
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 60 : 298 - 307
  • [42] Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol
    Qingxia Guan
    Shuang Sun
    Xiuyan Li
    Shaowa Lv
    Ting Xu
    Jialin Sun
    Wenjing Feng
    Liang Zhang
    Yongji Li
    Journal of Materials Science: Materials in Medicine, 2016, 27
  • [43] Preparation of glucagon-like peptide-1 loaded PLGA microspheres:: Characterizations, release studies and bioactivities in vitro/in vivo
    Yin, Dongfeng
    Lu, Ying
    Zhang, He
    Zhang, Guoqing
    Zou, Hao
    Sun, Duxin
    Zhong, Yanqiang
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (02) : 156 - 161
  • [44] Liraglutide-loaded poly(lactic-co-glycolic acid) microspheres: Preparation and in vivo evaluation
    Wu, Junzi
    Williams, Gareth R.
    Branford-White, Christopher
    Li, Heyu
    Li, Yan
    Zhu, Li-Min
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 92 : 28 - 38
  • [45] Development of puerarin-loaded poly(lactic acid) microspheres for sustained ocular delivery: In vitro/vivo / vivo evaluation
    Long, Yanqiu
    Hu, Jie
    Liu, Yan
    Wu, Danqing
    Zheng, Zhiyun
    Gui, Shuangying
    He, Ning
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2024, 204
  • [46] PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo
    Su, Yue
    Liu, Jia
    Tan, Songwen
    Liu, Wenfang
    Wang, Rongrong
    Chen, Chuanpin
    DRUG DELIVERY, 2022, 29 (01) : 1437 - 1446
  • [47] Paclitaxel-loaded poly(lactic-co-glycolic acid) microspheres: preparation and in vitro evaluation
    Achim, M.
    Tomuta, I.
    Vlase, L.
    Iuga, C.
    Moldovan, M.
    Leucuta, S. E.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2008, 18 (06) : 410 - 416
  • [48] Budesonide-Loaded Guar Gum Microspheres for Colon Delivery: Preparation, Characterization and in Vitro/in Vivo Evaluation
    Liu, Ye
    Zhou, Hong
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (02) : 2693 - 2704
  • [49] Preparation and in vitro/in vivo evaluation of uniform-sized Goserelin-loaded sustained release microspheres
    Qin, Ying
    Wei, Yi
    Gao, Zejing
    Liu, Jingxuan
    Sui, Donglin
    Hu, Yuning
    Gong, Fangling
    Ma, Guanghui
    JOURNAL OF CONTROLLED RELEASE, 2024, 375 : 745 - 757
  • [50] PLGA-based microspheres loaded with metformin hydrochloride: Modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
    Chauhan, Priyanka
    Paliwal, Himanshu
    Chauhan, Chetan Singh
    Paliwal, Ankit
    ANNALES PHARMACEUTIQUES FRANCAISES, 2023, 81 (06): : 997 - 1006
12345