Preparation and in Vitro/in Vivo Evaluation of Insulin-Loaded Poly(Acryloyl-Hydroxyethyl Starch)-PLGA Composite Microspheres

被引:0
|
作者
Ge Jiang
Wei Qiu
Patrick P. DeLuca
机构
[1] University of Kentucky ,Pharmaceutical Sciences
[2] College of Pharmacy,undefined
来源
Pharmaceutical Research | 2003年 / 20卷
关键词
PLGA; hydroxyethyl starch; microsphere; insulin; controlled release;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose. The purpose of this study was to develop and evaluate a novel composite microsphere delivery system composed of poly(D,L-lactide-co-glycolide) (PLGA) and poly(acryloyl hydroxyethyl starch) (acryloyl derivatized HES; AcHES) hydrogel using bovine insulin as a model therapeutic protein.
引用
收藏
页码:452 / 459
页数:7
相关论文
共 50 条
  • [31] Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles
    Yang, J.
    Sun, H.
    Song, C.
    DIABETES OBESITY & METABOLISM, 2012, 14 (04): : 358 - 364
  • [32] Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo
    Sun, Zheng
    Gu, Xuejing
    Hao, Teng
    Liu, Jiali
    Gao, Rongrong
    Li, Yanli
    Yu, Bin
    Xu, Hui
    DRUG DELIVERY, 2022, 29 (01) : 3317 - 3327
  • [33] Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection
    Park, Chun-Woong
    Lee, Hyo-Jung
    Oh, Dong-Won
    Kang, Ji-Hyun
    Han, Chang-Soo
    Kim, Dong-Wook
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2018, 12 : 711 - 719
  • [34] Preparation and in vitro evaluation of Bromhexine-HCl loaded poly(lactic acid) microspheres
    Sensoy, D.
    Uzunkaya, G.
    Bergisadi, N.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 32 (01) : S37 - S37
  • [35] In vitro/in vivo evaluation of the efficacy of gatifloxacine-loaded PLGA and hydroxyapatite composite for treating osteomyelitis
    Makiishi, Jun
    Matsuno, Tomonori
    Ito, Atsuo
    Sogo, Yu
    Satoh, Tazuko
    DENTAL MATERIALS JOURNAL, 2017, 36 (06) : 714 - 723
  • [36] Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro
    Jingyi Lu
    Baijie Ren
    Lei Wang
    Minghe Li
    Yue Liu
    Inflammation, 2020, 43 : 168 - 178
  • [37] Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro
    Lu, Jingyi
    Ren, Baijie
    Wang, Lei
    Li, Minghe
    Liu, Yue
    INFLAMMATION, 2020, 43 (01) : 168 - 178
  • [38] PREPARATION AND IN VITRO EVALUATION OF FELODIPINE-LOADED POLY(ε-CAPROLACTONE) MICROSPHERES: QUALITY BY DESIGN APPROACH
    Achim, Marcela
    Tefas, Lucia Ruxandra
    Iovanov, Rares
    Vonica-Gligor, Andreea Loredana
    Barbu-Tudoran, Lucian
    Tomuta, Ioan
    FARMACIA, 2019, 67 (04) : 670 - 683
  • [39] Preparation, Characterization and in vitro/vivo Evaluation of Long-Acting Rivaroxaban-Loaded Microspheres
    Tan, Chunli
    Xiong, Subin
    CURRENT DRUG DELIVERY, 2023, 20 (10) : 1547 - 1558
  • [40] Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol
    Guan, Qingxia
    Sun, Shuang
    Li, Xiuyan
    Lv, Shaowa
    Xu, Ting
    Sun, Jialin
    Feng, Wenjing
    Zhang, Liang
    Li, Yongji
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2016, 27 (02) : 1 - 13