NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

被引：0
|
作者：
Hexin Shi
Ying Wang
Xiaohong Li
Xiaoming Zhan
Miao Tang
Maggy Fina
Lijing Su
David Pratt
Chun Hui Bu
Sara Hildebrand
Stephen Lyon
Lindsay Scott
Jiexia Quan
Qihua Sun
Jamie Russell
Stephanie Arnett
Peter Jurek
Ding Chen
Vladimir V Kravchenko
John C Mathison
Eva Marie Y Moresco
Nancy L Monson
Richard J Ulevitch
Bruce Beutler
机构：
[1] Center for the Genetics of Host Defense,Department of Neurology and Neurotherapeutics
[2] University of Texas Southwestern Medical Center,Department of Immunology and Microbial Sciences
[3] University of Texas Southwestern Medical Center,undefined
[4] The Scripps Research Institute,undefined
来源：
Nature Immunology | 2016年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts NLRP3 activation to interphase of the cell cycle.
引用
收藏
页码：250 / 258
页数：8
相关论文
共 50 条
  • [41] Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors
    Zhao, Ni
    Li, Cui-cui
    Di, Bin
    Xu, Li-li
    JOURNAL OF AUTOIMMUNITY, 2020, 113
  • [42] An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7
    Caseley, Emily A.
    Lara-Reyna, Samuel
    Poulter, James A.
    Topping, Joanne
    Carter, Clive
    Nadat, Fatima
    Spickett, Gavin P.
    Savic, Sinisa
    McDermott, Michael F.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2022, 42 (01) : 158 - 170
  • [43] An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7
    Emily A. Caseley
    Samuel Lara-Reyna
    James A. Poulter
    Joanne Topping
    Clive Carter
    Fatima Nadat
    Gavin P. Spickett
    Sinisa Savic
    Michael F. McDermott
    Journal of Clinical Immunology, 2022, 42 : 158 - 170
  • [44] GUT MICROBIAL PRODUCTS AND SATURATED FATTY ACIDS LEAD TO NITRERGIC ENTERIC NEURONAL PYROPTOSIS VIA ACTIVATION OF ROS-MEDIATED NEK7/NLRP3 INFLAMMASOME PATHWAY
    Ye, Lan
    Goebel, Anna
    Li, Ge
    Mwangi, Simon M.
    Hu, Wenhui
    Srinivasan, Shanthi
    GASTROENTEROLOGY, 2018, 154 (06) : S55 - S55
  • [45] Nek7与NLRP3炎性小体激活机制的研究进展
    佟颖
    孙乐
    刁志惠
    杨华森
    王晨彤
    李智
    张伟平
    邵忠林
    杨俊朝
    生命的化学, 2018, 38 (03) : 367 - 372
  • [46] CANE, a Component of the NLRP3 Inflammasome, fl ammasome, Promotes Inflammasome fl ammasome Activation
    Kaneko, Naoe
    Kurata, Mie
    Yamamoto, Toshihiro
    Sakamoto, Akimasa
    Takada, Yasutsugu
    Kosako, Hidetaka
    Takeda, Hiroyuki
    Sawasaki, Tatsuya
    Masumoto, Junya
    JOURNAL OF IMMUNOLOGY, 2024, 213 (01):
  • [47] NEK7 inhibition attenuates Aβ42-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice
    Li, Peng
    He, Yifan
    Yang, Qian
    Guo, Hena
    Li, Nini
    Zhang, Dongdong
    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2023, : 145 - 153
  • [48] NEK7 inhibition attenuates Aβ42-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice
    Li, Peng
    He, Yifan
    Yang, Qian
    Guo, Hena
    Li, Nini
    Zhang, Dongdong
    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2023, 73 (02) : 145 - 153
  • [49] NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
    Xueliang Chen
    Ganglei Liu
    Yuanyuan Yuan
    Guotao Wu
    Shalong Wang
    Lianwen Yuan
    Cell Death & Disease, 10
  • [50] NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
    Chen, Xueliang
    Liu, Ganglei
    Yuan, Yuanyuan
    Wu, Guotao
    Wang, Shalong
    Yuan, Lianwen
    CELL DEATH & DISEASE, 2019, 10 (12)
12345