NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

被引：0

作者：

Hexin Shi

Ying Wang

Xiaohong Li

Xiaoming Zhan

Miao Tang

Maggy Fina

Lijing Su

David Pratt

Chun Hui Bu

Sara Hildebrand

Stephen Lyon

Lindsay Scott

Jiexia Quan

Qihua Sun

Jamie Russell

Stephanie Arnett

Peter Jurek

Ding Chen

Vladimir V Kravchenko

John C Mathison

Eva Marie Y Moresco

Nancy L Monson

Richard J Ulevitch

Bruce Beutler

机构：

[1] Center for the Genetics of Host Defense,Department of Neurology and Neurotherapeutics

[2] University of Texas Southwestern Medical Center,Department of Immunology and Microbial Sciences

[3] University of Texas Southwestern Medical Center,undefined

[4] The Scripps Research Institute,undefined

来源：

Nature Immunology | 2016年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts NLRP3 activation to interphase of the cell cycle.

引用

页码：250 / 258

页数：8

共 50 条

[31] MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation
Park, Yeon-Ji
Dodantenna, Niranjan
Kim, Yonghyeon
Kim, Tae-Hwan
Lee, Ho-Soo
Yoo, Young-Suk
Heo, June
Lee, Jae-Ho
Kwon, Myung-Hee
Kang, Ho Chul
Lee, Jong-Soo
Cho, Hyeseong
EMBO JOURNAL, 2023, 42 (19):
[32] OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
He, Chunlei
Wu, Qiang
Zeng, Zhaogan
Yang, Yadong
He, Huabin
Hu, Meiyu
Liu, Sheng
AUTOIMMUNITY, 2024, 57 (01)
[33] ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
Zheng, Sihao
Que, Xiangyong
Wang, Shuxian
Zhou, Qi
Xing, Xiaoke
Chen, Liang
Hou, Chunyan
Ma, Junfeng
An, Ping
Peng, Yihan
Yao, Yi
Song, Qibin
Li, Juanjuan
Zhang, Pingfeng
Pei, Huadong
MOLECULAR CELL, 2023, 83 (24) : 4570 - 4585.e7
[34] The PGAM5-NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
Gao, Cheng-Long
Song, Jinqian
Wang, Haojie
Shang, Qinghong
Guan, Xin
Xu, Gang
Wu, Jiayang
Wu, Dalei
Zheng, Yueqin
Wu, Xudong
Zhao, Feng
Liu, Xindong
Shi, Lei
Pang, Tao
ACTA PHARMACEUTICA SINICA B, 2025, 15 (01) : 349 - 370
[35] NEK7-Mediated Activation of NLRP3 Inflammasome Is Coordinated by Potassium Efflux/Syk/JNK Signaling During Staphylococcus aureus Infection
Liu, Ruiqing
Liu, Yashan
Liu, Chang
Gao, Aijiao
Wang, Lin
Tang, Huixin
Wu, Qiang
Wang, Xia
Tian, Derun
Qi, Zhi
Shen, Yanna
FRONTIERS IN IMMUNOLOGY, 2021, 12
[36] Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation
Zhang, Zhenxing
Chen, Chao
Liu, Caiyun
Sun, Pengkai
Liu, Ping
Fang, Shu
Li, Xinjian
SCIENCE ADVANCES, 2025, 11 (10):
[37] Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction
Li, Qiang
Feng, Hui
Wang, Hongbo
Wang, Yinghao
Mou, Wenqing
Xu, Guang
Zhang, Ping
Li, Ruisheng
Shi, Wei
Wang, Zhilei
Fang, Zhie
Ren, Lutong
Wang, Yan
Lin, Li
Hou, Xiaorong
Dai, Wenzhang
Li, Zhiyong
Wei, Ziying
Liu, Tingting
Wang, Jiabo
Guo, Yuming
Li, Pengyan
Zhao, Xu
Zhan, Xiaoyan
Xiao, Xiaohe
Bai, Zhaofang
EMBO REPORTS, 2022, 23 (02)
[38] LMP7 inhibits the activation of NLRP3 inflammasome through interaction with NLRP3
Jin, Jing
Wang, Wenbiao
Li, Aixin
Wu, Jianguo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 531 (02) : 152 - 159
[39] NLRP3 Ubiquitination-A New Approach to Target NLRP3 Inflammasome Activation
Akther, Mahbuba
Haque, Md Ezazul
Park, Jooho
Kang, Tae-Bong
Lee, Kwang-Ho
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
[40] Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation
El-Sayed, Sherihan
Freeman, Sally
Bryce, Richard A.
PROTEIN SCIENCE, 2022, 31 (10)

← 1 2 3 4 5 →