NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

被引：0
|
作者：
Hexin Shi
Ying Wang
Xiaohong Li
Xiaoming Zhan
Miao Tang
Maggy Fina
Lijing Su
David Pratt
Chun Hui Bu
Sara Hildebrand
Stephen Lyon
Lindsay Scott
Jiexia Quan
Qihua Sun
Jamie Russell
Stephanie Arnett
Peter Jurek
Ding Chen
Vladimir V Kravchenko
John C Mathison
Eva Marie Y Moresco
Nancy L Monson
Richard J Ulevitch
Bruce Beutler
机构：
[1] Center for the Genetics of Host Defense,Department of Neurology and Neurotherapeutics
[2] University of Texas Southwestern Medical Center,Department of Immunology and Microbial Sciences
[3] University of Texas Southwestern Medical Center,undefined
[4] The Scripps Research Institute,undefined
来源：
Nature Immunology | 2016年 / 17卷
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D O I：
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学科分类号：
摘要：
NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts NLRP3 activation to interphase of the cell cycle.
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收藏
页码：250 / 258
页数：8
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