Synthesis of hydrogels based on silicon polyolates

被引：0
|
作者：
T. G. Khonina
E. V. Shadrina
A. A. Boyko
O. N. Chupakhin
L. P. Larionov
A. A. Volkov
V. D. Burda
机构：
[1] Ural Branch of the Russian Academy of Sciences,I. Ya. Postovsky Institute of Organic Synthesis
[2] Ural State Medical Academy of the Federal Agency on the Health Care and Social Development of Russia,undefined
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
Key words; organosilicon compounds; diols; glycerol; silicon polyolates; hydrogels; trans-cutaneous properties; wound-healing activity; ointment bases;
D O I：
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学科分类号：
摘要：
Biologically active hydrogels based on silicon polyolates, which are the products of reactions of tetraethoxy- and methyltriethoxysilanes with polyols (1,2-propanediol, glycerol, polyethylene glycol), were synthesized. The optimal conditions for hydrogel formation and hydrogel composition were determined. The acute toxicity and transcutaneous and wound-healing activities of the synthesized compounds were studied. The experimental results show that hydrogels based on silicon polyolates can be recommended for further preclinical and clinical tests with the purpose of their use in medical practice both as self-sufficient agents and ointment bases of pharmaceutical compositions with wound-healing, regenerative, and transcutaneous action.
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页码：75 / 80
页数：5
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