Synthesis of hydrogels based on silicon polyolates

被引：12
|
作者：
Khonina, T. G. [1 ]
Shadrina, E. V. [1 ]
Boyko, A. A. [1 ]
Chupakhin, O. N. [1 ]
Larionov, L. P. [2 ]
Volkov, A. A. [2 ]
Burda, V. D. [2 ]
机构：
[1] Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620041, Russia
[2] Fed Agcy Hlth Care & Social Dev Russia, Ural State Med Acad, Ekaterinburg 620219, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
organosilicon compounds; diols; glycerol; silicon polyolates; hydrogels; transcutaneous properties; wound-healing activity; ointment bases;
D O I：
10.1007/s11172-010-0047-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biologically active hydrogels based on silicon polyolates, which are the products of reactions of tetraethoxy- and methyltriethoxysilanes with polyols (1,2-propanediol, glycerol, polyethylene glycol), were synthesized. The optimal conditions for hydrogel formation and hydrogel composition were determined. The acute toxicity and transcutaneous and wound-healing activities of the synthesized compounds were studied. The experimental results show that hydrogels based on silicon polyolates can be recommended for further preclinical and clinical tests with the purpose of their use in medical practice both as self-sufficient agents and ointment bases of pharmaceutical compositions with wound-healing, regenerative, and transcutaneous action.
引用
收藏
页码：75 / 80
页数：6
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