Synthesis of pharmacologically active hydrogels based on combined silicon and titanium polyolates

被引：6
|
作者：
Ivanenko, M. V. [1 ]
Khonina, T. G. [1 ]
Chupakhin, O. N. [1 ,2 ]
Larionov, L. P. [3 ]
Sakhautdinova, R. R. [3 ]
Safronov, A. P. [2 ,4 ]
机构：
[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, Ekaterinburg 620041, Russia
[2] Ural Fed Univ, Ekaterinburg 620002, Russia
[3] Minist Hlth Protect & Social Dev, Ural State Med Acad, Ekaterinburg 620219, Russia
[4] Russian Acad Sci, Ural Branch, Inst Electrophys, Ekaterinburg 620016, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2012年 / 61卷 / 11期
基金：
俄罗斯基础研究基金会;
关键词：
silicon and titanium polyolates; silicon-titanium hydrogels; wound healing; regenerating; transcutaneous activity; MODIFIED SILANES; MONOLITHS; CHEMISTRY;
D O I：
10.1007/s11172-012-0303-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The target synthesis of new biologically active hydrogels based on combined silicon and titanium polyolates was carried out. The optimum conditions for hydrogel formation and their composition were determined. The type of hydrogels and mechanisms of gelation depend on the nature of polyols: gels based on combined silicon and titanium polyethylene glycolates are polymeric and formed via the polycondensation mechanism, whereas gels based on combined silicon and titanium glycerolates are colloidal and formed via the coagulation-condensation mechanism. The combined hydrogels based on silicon dimethyl glycerolates and titanium tetraglycerolate exhibit enhanced transcutaneous, wound healing, and regenerating activity.
引用
收藏
页码：2163 / 2171
页数：9
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