Synthesis of hydrogels based on silicon polyolates

被引：0
|
作者：
T. G. Khonina
E. V. Shadrina
A. A. Boyko
O. N. Chupakhin
L. P. Larionov
A. A. Volkov
V. D. Burda
机构：
[1] Ural Branch of the Russian Academy of Sciences,I. Ya. Postovsky Institute of Organic Synthesis
[2] Ural State Medical Academy of the Federal Agency on the Health Care and Social Development of Russia,undefined
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
Key words; organosilicon compounds; diols; glycerol; silicon polyolates; hydrogels; trans-cutaneous properties; wound-healing activity; ointment bases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biologically active hydrogels based on silicon polyolates, which are the products of reactions of tetraethoxy- and methyltriethoxysilanes with polyols (1,2-propanediol, glycerol, polyethylene glycol), were synthesized. The optimal conditions for hydrogel formation and hydrogel composition were determined. The acute toxicity and transcutaneous and wound-healing activities of the synthesized compounds were studied. The experimental results show that hydrogels based on silicon polyolates can be recommended for further preclinical and clinical tests with the purpose of their use in medical practice both as self-sufficient agents and ointment bases of pharmaceutical compositions with wound-healing, regenerative, and transcutaneous action.
引用
收藏
页码：75 / 80
页数：5
相关论文
共 50 条
  • [31] Acrylic hydrogels-based biocomposites: Synthesis and characterization
    Sandu, Teodor
    Sarbu, Andrei
    Constantin, Floriana
    Vulpe, Silviu
    Iovu, Horia
    JOURNAL OF APPLIED POLYMER SCIENCE, 2013, 127 (05) : 4061 - 4071
  • [32] Synthesis and characterisation of hydrogels based on poly(vinyl pyrrolidone)
    Benamer, S.
    Mahlous, M.
    Boukrif, A.
    Mansouri, B.
    Youcef, S. Larbi
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2006, 248 (02): : 284 - 290
  • [33] Valve based on novel hydrogels: From synthesis to application
    Romero, Marcelo R.
    Arrua, R. Dario
    Alvarez Igarzabal, Cecilia I.
    Hilder, Emily F.
    SENSORS AND ACTUATORS B-CHEMICAL, 2013, 188 : 176 - 184
  • [34] Synthesis and swelling behavior of hydrogels based on crafted chitosan
    Yazdani-Pedram, M
    Retuert, J
    BIOMEDICAL MATERIALS-DRUG DELIVERY, IMPLANTS AND TISSUE ENGINEERING, 1999, 550 : 29 - 34
  • [35] Synthesis and characterization of superabsorbent hydrogels composites based on polysuccinimide
    Yang, Jun
    Fang, Li
    Tan, Tianwei
    JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 102 (01) : 550 - 557
  • [36] A study in the synthesis and characterization of dextrin and acrylamides based hydrogels
    Chauhan, GS
    Kumari, A
    Sharma, R
    JOURNAL OF POLYMER MATERIALS, 2003, 20 (03): : 327 - 335
  • [37] Synthesis and Swelling Properties of Thermosensitive Hydrogels based on Terpolymerization
    Cai Hua NI1
    Chinese Chemical Letters, 2005, (05) : 675 - 676
  • [38] Synthesis of novel lactose-based hydrogels.
    Zhou, WJ
    Hsieh, YL
    Kurth, MJ
    Krochta, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U73 - U73
  • [39] Synthesis and characterization of cyclic acetal based degradable hydrogels
    Kaihara, Sachiko
    Matsumura, Shuichi
    Fisher, John P.
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2008, 68 (01) : 67 - 73
  • [40] SYNTHESIS OF NEW HYDROGELS BASED ON XANTHAN AND CELLULOSE ALLOMORPHS
    Ciolacu, Diana
    Cazacu, Maria
    CELLULOSE CHEMISTRY AND TECHNOLOGY, 2011, 45 (3-4): : 163 - 169
12345