Genetics of IL28B and HCV—response to infection and treatment

被引：0
|
作者：
C. Nelson Hayes
Michio Imamura
Hiroshi Aikata
Kazuaki Chayama
机构：
[1] Applied Life Sciences,Department of Gastroenterology and Metabolism
[2] Institute of Biomedical and Health Sciences,undefined
[3] Hiroshima University,undefined
来源：
Nature Reviews Gastroenterology & Hepatology | 2012年 / 9卷
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摘要：
The role ofIL28B in chronic HCV infection has been studied extensively since a series of genome-wide association studies linked the IL28B locus to response to HCV therapy. In this Review, the authors provide a summary of the role of IL28B in HCV infection, describing how IL28Bgenetics affect viral dynamics, host immune response to the virus and response to therapy.
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页码：406 / 417
页数：11
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