Genetics of IL28B and HCV—response to infection and treatment

被引：0
|
作者：
C. Nelson Hayes
Michio Imamura
Hiroshi Aikata
Kazuaki Chayama
机构：
[1] Applied Life Sciences,Department of Gastroenterology and Metabolism
[2] Institute of Biomedical and Health Sciences,undefined
[3] Hiroshima University,undefined
来源：
Nature Reviews Gastroenterology & Hepatology | 2012年 / 9卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role ofIL28B in chronic HCV infection has been studied extensively since a series of genome-wide association studies linked the IL28B locus to response to HCV therapy. In this Review, the authors provide a summary of the role of IL28B in HCV infection, describing how IL28Bgenetics affect viral dynamics, host immune response to the virus and response to therapy.
引用
收藏
页码：406 / 417
页数：11
相关论文
共 50 条
  • [1] Genetics of IL28B and HCV-response to infection and treatment
    Hayes, C. Nelson
    Imamura, Michio
    Aikata, Hiroshi
    Chayama, Kazuaki
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2012, 9 (07) : 406 - 417
  • [2] IL28B GENETIC VARIATION AND TREATMENT RESPONSE IN PATIENTS WITH HCV GENOTYPE 3 INFECTION
    Dalgard, Olav
    Moghaddam, Amir
    Verbaan, Hans
    Ring-Larsen, Helmer
    Bjoro, Kristian
    Melum, Espen
    HEPATOLOGY, 2010, 52 (04) : 751A - 751A
  • [3] IL28B genotype on HCV infection in Asia
    Liu C.-H.
    Kao J.-H.
    Current Hepatitis Reports, 2013, 12 (3) : 149 - 156
  • [4] IL28B Polymorphisms as a Pretreatment Predictor of Response to HCV Treatment
    Berger, Christoph T.
    Kim, Arthur Y.
    INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2012, 26 (04) : 863 - +
  • [5] IL28B POLYMORPHISMS ARE ASSOCIATED WITH HISTOLOGICAL RECURRENCE AND TREATMENT RESPONSE FOLLOWING LIVER TRANSPLANTATION IN PATIENTS WITH HCV WITH HCV INFECTION
    Charlton, Michael R.
    Thompson, Alexander J.
    Veldt, Bart J.
    Watt, Kymberly D.
    Tillmann, Hans L.
    Poterucha, John J.
    Heimbach, Julie
    Goldstein, David B.
    McHutchison, John G.
    HEPATOLOGY, 2010, 52 (04) : 320A - 320A
  • [6] IL28B genotyping and treatment of HCV infected subjects
    Novotny, Dalibor
    Roubalova, Lucie
    Aiglova, Kvetoslava
    Bednarikova, Jana
    Bartkova, Margita
    ASIAN BIOMEDICINE, 2014, 8 (04) : 445 - 452
  • [7] New advances in IL28B genetics
    Katherine Smith
    Nature Reviews Gastroenterology & Hepatology, 2013, 10 (7) : 385 - 385
  • [8] Impact of Immunogenetic IL28B Polymorphism on Natural Outcome of HCV Infection
    De Re, Valli
    Gragnani, Laura
    Fognani, Elisa
    Piluso, Alessia
    Izzo, Francesco
    Mangia, Alessandra
    Crovatto, Marina
    Gava, Graziella
    Casarin, Pietro
    Sansonno, Domenico
    Racanelli, Vito
    De Vita, Salvatore
    Pioltelli, Pietro
    Caggiari, Laura
    De Zorzi, Mariangela
    Berretta, Massimiliano
    Gini, Andrea
    Zucchetto, Antonella
    Buonaguro, Franco Maria
    De Paoli, Paolo
    Zignego, Anna Linda
    BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [9] Tryptophan Breakdown in Patients with HCV Infection is Influenced by IL28B Polymorphism
    Zoller, Heinz
    Jenal, Annina
    Staettermayer, Albert F.
    Schroecksnadel, Sebastian
    Ferenci, Peter
    Fuchs, Dietmar
    PHARMACEUTICALS, 2015, 8 (02): : 337 - 350
  • [10] SNP rs8099917 in Gene IL28B Might Be Associated with Risk of Chronic Infection by HCV but Not with Response to Treatment
    Souza da Silva Conde, Simone Regina
    Mendes Soares Monteiro, Julius Caesar
    Silva dos Santos, Bruna Tereza
    Fonseca Filgueiras, Nathalia Karla
    de Almeida Lins, Pedro Alves
    Freitas, Felipe Bonfim
    Graca, Ednelza da Silva
    Demachki, Samia
    Ferreira de Araujo, Marialva Tereza
    Ishak, Ricardo
    Rosario Vallinoto, Antonio Carlos
    BIOMED RESEARCH INTERNATIONAL, 2014, 2014
12345