Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

被引:0
|
作者
K. Højlund
J. F. P. Wojtaszewski
J. Birk
B. F. Hansen
H. Vestergaard
H. Beck-Nielsen
机构
[1] Odense University Hospital,Diabetes Research Centre, Department of Endocrinology
[2] University of Copenhagen,Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology
[3] Novo Nordisk,Diabetes Biology
[4] University of Copenhagen,Department of Endocrinology, Herlev Hospital
[5] Odense University Hospital,Department of Endocrinology
来源
Diabetologia | 2006年 / 49卷
关键词
Glucose metabolism; Glycogen synthase; Insulin clearance; Insulin receptor mutation; Insulin signalling;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1827 / 1837
页数:10
相关论文
共 50 条
  • [31] DELAYED-ONSET OF INSULIN ACTIVATION OF THE INSULIN-RECEPTOR KINASE IN-VIVO IN HUMAN SKELETAL-MUSCLE
    FREIDENBERG, GR
    SUTER, S
    HENRY, RR
    NOLAN, J
    REICHART, D
    OLEFSKY, JM
    DIABETES, 1994, 43 (01) : 118 - 126
  • [32] Endothelin-1 infusion in vivo decreases insulin clearance and causes acute muscle insulin resistance through impaired capillary perfusion
    Ross, R. M.
    Rattigan, S.
    Clark, M. G.
    DIABETOLOGIA, 2006, 49 : 373 - 373
  • [33] Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling
    Prats, Clara
    Gomez-Cabello, Alba
    Hansen, Andreas V.
    EXPERIMENTAL PHYSIOLOGY, 2011, 96 (04) : 385 - 390
  • [34] Phenotypical variety of insulin resistance in a family with a novel mutation of insulin receptor gene
    Takahashi, Ikuko
    Yamada, Yuichiro
    Koizumi, Akio
    Takahashi, Tsutomu
    HORMONE RESEARCH, 2009, 72 : 333 - 333
  • [35] Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene
    Takahashi, Ikuko
    Yamada, Yuichiro
    Kadowaki, Hiroko
    Horikoshi, Momoko
    Kadowaki, Takashi
    Narita, Takuma
    Tsuchida, Satoko
    Noguchi, Atsuko
    Koizumi, Akio
    Takahashi, Tsutomu
    ENDOCRINE JOURNAL, 2010, 57 (06) : 509 - 516
  • [36] INSULIN-RECEPTOR SIGNALING IS IMPAIRED IN SKELETAL-MUSCLE FROM OBESE PATIENTS
    GOODYEAR, LJ
    SHERMAN, LA
    GIORGINO, F
    CAREY, J
    SMITH, RJ
    DOHM, GL
    DIABETES, 1994, 43 : A146 - A146
  • [37] A Case of Short Stature, Hirsutism and Severe Insulin Resistance Associated with a Novel Heterozygous Mutation of Insulin Receptor
    Pannunzi, Laura Proietti
    Motta, Cecilia
    Grasso, Valeria
    Toscano, Vincenzo
    Barbetti, Fabrizio
    DIABETES, 2011, 60 : A416 - A416
  • [38] Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor
    Zhu, Canjun
    Xu, Zhiyue
    Yuan, Yexian
    Wang, Tao
    Xu, Chang
    Yin, Cong
    Xie, Peipei
    Xu, Pingwen
    Ye, Hui
    Patel, Nirali
    Schaul, Sarah
    Wang, Lina
    Zhu, Xiaotong
    Wang, Songbo
    Gao, Ping
    Xi, Qianyun
    Zhang, Yongliang
    Shu, Gang
    Jiang, Qingyan
    ENDOCRINOLOGY DIABETES & METABOLISM, 2021, 4 (03)
  • [39] Severe neonatal insulin-resistance caused by compound heterozygous mutations in the insulin receptor gene
    Ruiz-Arana, Inge
    Martin-Frias, Maria
    Alegre, Maria
    Garin, Intza
    Perez de Nanclares, Guiomar
    Alonso, Milagros
    HORMONE RESEARCH, 2009, 72 : 422 - 422
  • [40] Impaired insulin action despite upregulation of proximal insulin signaling: Novel insights into skeletal muscle insulin resistance in liver cirrhosis
    Jessen, Niels
    Buhl, Esben Selmer
    Schmitz, Ole
    Lund, Sten
    JOURNAL OF HEPATOLOGY, 2006, 45 (06) : 797 - 804