Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

被引：0
|
作者：
S. B. Seredenin
G. A. Romanova
T. A. Gudasheva
F. M. Shakova
I. V. Barskov
E. V. Stelmashuk
T. A. Antipova
机构：
[1] Russian Academy of Medical Sciences,V. V. Zakusov Institute of Pharmacology
[2] Russian Academy of Medical Sciences,Department of Brain Studies, Neurology Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 150卷
关键词：
nerve growth factor mimetic; photoinduced thrombosis; GK-2 dipeptide; neuroprotection; antiamnestic effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.
引用
收藏
页码：432 / 435
页数：3
相关论文
共 50 条
  • [31] Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells
    Antipova, T. A.
    Deev, I. E.
    Gudasheva, T. A.
    Nikolaev, S. V.
    Logvinov, I. O.
    Serova, O. V.
    Gavrilenkova, A. A.
    Povarnina, P. Yu.
    Tarasiuk, A. V.
    Vakhitova, Yu. V.
    Seredenin, S. B.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 56 (12) : 1568 - 1572
  • [32] Nerve growth factor novel dipeptide mimetic GK-2 selectively activates TrkA postreceptor signaling pathways and does not cause adverse effects of native neurotrophin
    Gudasheva, T. A.
    Antipova, T. A.
    Konstantinopolsky, M. A.
    Povarnina, P. Yu.
    Seredenin, S. B.
    [J]. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2014, 456 (01) : 88 - 91
  • [33] Nerve growth factor novel dipeptide mimetic GK-2 selectively activates TrkA postreceptor signaling pathways and does not cause adverse effects of native neurotrophin
    T. A. Gudasheva
    T. A. Antipova
    M. A. Konstantinopolsky
    P. Yu. Povarnina
    S. B. Seredenin
    [J]. Doklady Biochemistry and Biophysics, 2014, 456 : 88 - 91
  • [34] A new nerve growth factor mimetic dipeptide GK-2 protects neurons from oxidative stress, glutamate toxicity and MPTP-induced injure in vitro
    Antipova, T.
    Gudasheva, T.
    Seredenin, S.
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010, 13 : 183 - 183
  • [35] THE NERVE GROWTH FACTOR MIMETIC GK-2 PROTECTS NEURONS IN POST-RESUSCITATIVE PERIOD AFTER CARDIAC ARREST IN RATS
    Avrushchenko, Maria Sh.
    Ostrova, Irina V.
    Zarzhetsky, Yuriy V.
    Gudasheva, Tatyana A.
    Seredenin, Sergey B.
    [J]. SHOCK, 2016, 46 (04): : 58 - 59
  • [36] The Effects of the Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices
    A. A. Volkova
    P. Yu. Povarnina
    P. D. Rogozin
    R. V. Kondratenko
    I. N. Sharonova
    A. A. Kamenskii
    V. G. Skrebitskii
    [J]. Neurochemical Journal, 2023, 17 : 219 - 223
  • [37] The Effects of the Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices
    Volkova, A. A.
    Povarnina, P. Yu.
    Rogozin, P. D.
    Kondratenko, R. V.
    Sharonova, I. N.
    Kamenskii, A. A.
    Skrebitskii, V. G.
    [J]. NEUROCHEMICAL JOURNAL, 2023, 17 (02) : 219 - 223
  • [38] Design, synthesis, and neuroprotective effects of a dimeric dipeptide mimetic of the third loop of the nerve growth factor
    Gudasheva, T. A.
    Tarasiuk, A. V.
    Sazonova, N. M.
    Pomogaibo, S. V.
    Shumskiy, A. N.
    Logvinov, I. O.
    Nikolaev, S. V.
    Povarnina, P. Yu.
    Konstantinopolsky, M. A.
    Antipova, T. A.
    Seredenin, S. B.
    [J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2017, 43 (03) : 235 - 247
  • [39] Design, synthesis, and neuroprotective effects of a dimeric dipeptide mimetic of the third loop of the nerve growth factor
    T. A. Gudasheva
    A. V. Tarasiuk
    N. M. Sazonova
    S. V. Pomogaibo
    A. N. Shumskiy
    I. O. Logvinov
    S. V. Nikolaev
    P. Yu. Povarnina
    M. A. Konstantinopolsky
    T. A. Antipova
    S. B. Seredenin
    [J]. Russian Journal of Bioorganic Chemistry, 2017, 43 : 235 - 247
  • [40] Neuroprotective Role of Nerve Growth Factor in Hypoxic-Ischemic Brain Injury
    Fantacci, Claudia
    Capozzi, Domenico
    Ferrara, Pietro
    Chiaretti, Antonio
    [J]. BRAIN SCIENCES, 2013, 3 (03): : 1013 - 1022
12345