Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

被引：0
|
作者：
S. B. Seredenin
G. A. Romanova
T. A. Gudasheva
F. M. Shakova
I. V. Barskov
E. V. Stelmashuk
T. A. Antipova
机构：
[1] Russian Academy of Medical Sciences,V. V. Zakusov Institute of Pharmacology
[2] Russian Academy of Medical Sciences,Department of Brain Studies, Neurology Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 150卷
关键词：
nerve growth factor mimetic; photoinduced thrombosis; GK-2 dipeptide; neuroprotection; antiamnestic effect;
D O I：
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学科分类号：
摘要：
The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.
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页码：432 / 435
页数：3
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