Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

被引：0
|
作者：
S. B. Seredenin
G. A. Romanova
T. A. Gudasheva
F. M. Shakova
I. V. Barskov
E. V. Stelmashuk
T. A. Antipova
机构：
[1] Russian Academy of Medical Sciences,V. V. Zakusov Institute of Pharmacology
[2] Russian Academy of Medical Sciences,Department of Brain Studies, Neurology Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 150卷
关键词：
nerve growth factor mimetic; photoinduced thrombosis; GK-2 dipeptide; neuroprotection; antiamnestic effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.
引用
收藏
页码：432 / 435
页数：3
相关论文
共 50 条
  • [1] Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex
    Seredenin, S. B.
    Romanova, G. A.
    Gudasheva, T. A.
    Shakova, F. M.
    Barskov, I. V.
    Stelmashuk, E. V.
    Antipova, T. A.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 150 (04) : 432 - 435
  • [2] Synthesis of GK-2, a Dimeric Dipeptide Nerve Growth Factor Mimetic and Potential Neuroprotective Agent
    Sazonova, N. M.
    Tarasyuk, A. V.
    Kurilov, D. V.
    Pomogaibo, S. V.
    Gudasheva, T. A.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (07) : 439 - 448
  • [3] Synthesis of GK-2, a Dimeric Dipeptide Nerve Growth Factor Mimetic and Potential Neuroprotective Agent
    N. M. Sazonova
    A. V. Tarasyuk
    D. V. Kurilov
    S. V. Pomogaibo
    T. A. Gudasheva
    [J]. Pharmaceutical Chemistry Journal, 2015, 49 : 439 - 448
  • [4] Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin
    Seredenin S.B.
    Silachev D.N.
    Gudasheva T.A.
    Pirogov Y.A.
    Isaev N.K.
    [J]. Bulletin of Experimental Biology and Medicine, 2011, 151 (5) : 584 - 587
  • [5] Neuroprotective Effect of GK-2, a Dipeptide Mimetic of Nerve Growth Factor, during Experimental Focal Ischemia in Middle Cerebral Artery Basin
    Seredenin, S. B.
    Silachev, D. N.
    Gudasheva, T. A.
    Pirogov, Yu. A.
    Isaev, N. K.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (05) : 584 - 587
  • [6] Antiparkinsonian Properties of a Nerve Growth Factor Dipeptide Mimetic GK-2 in in Vivo Experiments
    Povarnina, P. Yu.
    Gudasheva, T. A.
    Vorontsova, O. N.
    Bondarenko, N. A.
    Seredenin, S. B.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (06) : 690 - 693
  • [7] The delayed protective effect of GK-2, a dipeptide mimetic of Nerve Growth Factor, in a model of rat traumatic brain injury
    Genrikhs, Elisaveta E.
    Voronkov, Dmitriy N.
    Kapkaeva, Marina R.
    Gudasheva, Tatyana A.
    Glibka, Yuliya A.
    Isaev, Nickolay K.
    Stelmashook, Elena V.
    [J]. BRAIN RESEARCH BULLETIN, 2018, 140 : 148 - 153
  • [8] Antiparkinsonian Properties of a Nerve Growth Factor Dipeptide Mimetic GK-2 in in Vivo Experiments
    P. Yu. Povarnina
    T. A. Gudasheva
    O. N. Vorontsova
    N. A. Bondarenko
    S. B. Seredenin
    [J]. Bulletin of Experimental Biology and Medicine, 2011, 151 : 690 - 693
  • [9] Synthesis and In Vitro Neuroprotective Activity of Analogs with Various Spacer Lengths of a Dimeric Dipeptide Mimetic (GK-2) of Nerve Growth Factor
    A. V. Tarasyuk
    N. M. Sazonova
    D. V. Kurilov
    A. A. Lubin
    T. A. Antipova
    T. A. Gudasheva
    [J]. Pharmaceutical Chemistry Journal, 2019, 53 : 487 - 494
  • [10] Synthesis and In Vitro Neuroprotective Activity of Analogs with Various Spacer Lengths of a Dimeric Dipeptide Mimetic (GK-2) of Nerve Growth Factor
    Tarasyuk, A., V
    Sazonova, N. M.
    Kurilov, D., V
    Lubin, A. A.
    Antipova, T. A.
    Gudasheva, T. A.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (06) : 487 - 494
12345