Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

被引：9
|
作者：
Seredenin, S. B. [1 ]
Romanova, G. A. [1 ]
Gudasheva, T. A. [1 ]
Shakova, F. M. [1 ]
Barskov, I. V. [2 ]
Stelmashuk, E. V. [2 ]
Antipova, T. A. [1 ]
机构：
[1] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Moscow, Russia
[2] Russian Acad Med Sci, Dept Brain Studies, Neurol Res Ctr, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 150卷 / 04期
关键词：
nerve growth factor mimetic; photoinduced thrombosis; GK-2; dipeptide; neuroprotection; antiamnestic effect;
D O I：
10.1007/s10517-011-1161-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.
引用
收藏
页码：432 / 435
页数：4
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