Synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetra- hydropyrido[3,4-d]pyrimidine

被引：0
|
作者：
Kuznetsov A.Yu. [1 ]
Chapyshev S.V. [1 ]
机构：
[1] Institute for Problems of Chemical Physics, Russian Academy of Sciences
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 10期
关键词：
Condensation; Ethyl; 1-benzyl-3-oxopiperidine-4-carboxylate; Pyridinecarboxyamidines; Pyrido[3,4-d]pyrimidines;
D O I：
10.1007/s10593-007-0200-0
中图分类号：
学科分类号：
摘要：
A method has been developed for the synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine based on the condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with pyridyl-2-, pyridyl-3-, and pyridyl-4-carboxamidines and subsequent reactions of 7-benzyl-2-pyridyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-ones with trifluoromethanesulfonic anhydride and secondary amines. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：1320 / 1324
页数：4
相关论文
共 50 条
  • [21] Probing the Reactivity of 2,4-Dichlorofuro[3,4-d]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives
    Vincetti, Paolo
    Costantino, Gabriele
    Martina, Maria Grazia
    Radi, Marco
    SYNLETT, 2019, 30 (17) : 2010 - 2014
  • [22] SYNTHESIS OF 7-BENZYL-5,6,7,8-TETRAHYDRO-PYRIDO[4',3'-4,5]THIENO[2,3-D]PYRIMIDINE-4(3H)-ONS WITH ALKYLTHIOETHER GROUPS IN POSITION-2 AND EXAMINATION OF THEIR PLATELET-AGGREGATION INHIBITING ACTIVITY
    LEISTNER, S
    WAGNER, G
    GUTSCHOW, M
    GLUSA, E
    PHARMAZIE, 1986, 41 (01): : 54 - 55
  • [23] Synthesis of diethylammonium 3,4-dicyano-5,6,7,8-tetrahydroquinolin-2-olates
    M. Yu. Belikov
    O. V. Ershov
    A. V. Eremkin
    Ya. S. Kayukov
    O. E. Nasakin
    Russian Journal of Organic Chemistry, 2010, 46 : 615 - 616
  • [24] Design, synthesis, characterization, molecular docking studies and biological evaluation of 5, 6, 7, 8-tetrahydropyrido[3,4-d] pyrimidine derivatives as antimicrobial agents
    Varikuppla, Parusharam
    Kotha, Aruna Kumari
    Mullaguri, Sai Charitha
    Kancha, Rama Krishna
    Merugu, Ramchander
    Mittapelli, Vasantha
    CHEMICAL DATA COLLECTIONS, 2024, 53
  • [25] PYRIMIDINE-DERIVATIVES AND RELATED COMPOUNDS .14. SYNTHESIS OF N-SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES FROM PYRIMIDINE-DERIVATIVES
    SENDA, S
    YANG, G
    HIROTA, K
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1972, 20 (02) : 399 - +
  • [26] Synthesis of diethylammonium 3,4-dicyano-5,6,7,8-tetrahydroquinolin-2-olates
    Belikov, M. Yu.
    Ershov, O. V.
    Eremkin, A. V.
    Kayukov, Ya. S.
    Nasakin, O. E.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2010, 46 (04) : 615 - 616
  • [27] ISOXAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONES - SYNTHESIS OF 3-UNSUBSTITUTED DERIVATIVES - A REINVESTIGATION
    DALPIAZ, V
    CICIANI, G
    GIOVANNONI, MP
    TETRAHEDRON LETTERS, 1991, 32 (27) : 3229 - 3230
  • [28] Synthesis and characterization of some novel 7-substitued Benzopyrano [3,4-d]imidazoles derivatives
    Sadhana, K.
    Aruna, S.
    MATERIALS TODAY-PROCEEDINGS, 2021, 45 : 6969 - 6973
  • [29] Efficient Synthesis of 7-benzyl-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno [2,3-d]pyrimidin-4(3H)-Ones Via Aza-Wittig Reaction
    Chen, Hong
    Yan, Kai
    Liu, Ming-Guo
    LETTERS IN ORGANIC CHEMISTRY, 2011, 8 (09) : 644 - 647
  • [30] Synthesis and anti-HSV-1 activity of 6 substituted pyrazolo[3,4-d]pyridazin-7-one nucleosides
    Baraldi, PG
    Manfredini, S
    Romagnoli, R
    Stevanato, L
    Zaid, AN
    Manservigi, R
    NUCLEOSIDES & NUCLEOTIDES, 1998, 17 (12): : 2165 - 2173
12345