Synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetra- hydropyrido[3,4-d]pyrimidine

被引：0
|
作者：
Kuznetsov A.Yu. [1 ]
Chapyshev S.V. [1 ]
机构：
[1] Institute for Problems of Chemical Physics, Russian Academy of Sciences
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 10期
关键词：
Condensation; Ethyl; 1-benzyl-3-oxopiperidine-4-carboxylate; Pyridinecarboxyamidines; Pyrido[3,4-d]pyrimidines;
D O I：
10.1007/s10593-007-0200-0
中图分类号：
学科分类号：
摘要：
A method has been developed for the synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine based on the condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with pyridyl-2-, pyridyl-3-, and pyridyl-4-carboxamidines and subsequent reactions of 7-benzyl-2-pyridyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-ones with trifluoromethanesulfonic anhydride and secondary amines. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：1320 / 1324
页数：4
相关论文
共 50 条
  • [31] SYNTHESIS AND REACTIONS OF SUBSTITUTED 2H-PYRAZOLO[3,4-D]PYRIDAZIN-7(6H)-ONES AND THEIR ANTIBACTERIAL PROPERTIES
    PATEL, HV
    FERNANDES, PS
    VYAS, KA
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1990, 29 (10): : 966 - 969
  • [32] POTENTIAL PURINE ANTAGONISTS .7. SYNTHESIS OF 6-ALKYLPYRAZOLO-[3,4-D]PYRIMIDINES
    CHENG, CC
    ROBINS, RK
    JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (02): : 191 - 200
  • [33] A facile and novel synthesis of N2-, C6-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists
    Venkatesan, G.
    Paira, P.
    Cheong, S. L.
    Federico, S.
    Klotz, K. N.
    Spalluto, G.
    Pastorin, G.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 92 : 784 - 798
  • [34] Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents
    Cacciari, Barbara
    Romagnoli, Romeo
    Romani, Arianna
    Trentini, Alessandro
    Hanau, Stefania
    FUTURE MEDICINAL CHEMISTRY, 2021, 13 (18) : 1515 - 1530
  • [35] Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones
    Safaei, Shirin
    Mohammadpoor-Baltork, Iraj
    Khosropour, Ahmad Reza
    Moghadam, Majid
    Tangestaninejad, Shahram
    Mirkhani, Valiollah
    MOLECULAR DIVERSITY, 2012, 16 (03) : 591 - 600
  • [36] Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine-6(7H)-thiones
    Shirin Safaei
    Iraj Mohammadpoor-Baltork
    Ahmad Reza Khosropour
    Majid Moghadam
    Shahram Tangestaninejad
    Valiollah Mirkhani
    Molecular Diversity, 2012, 16 : 591 - 600
  • [37] SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME 7-[(2-HYDROXYETHOXY)METHYL]PYRAZOLO[3,4-D]PYRIMIDINE ANALOGS OF SANGIVAMYCIN AND TOYOCAMYCIN
    SAXENA, NK
    COLEMAN, LA
    DRACH, JC
    TOWNSEND, LB
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) : 1980 - 1983
  • [38] SYNTHESIS OF 2',2',10-TRIMETHYLDIHYDROPYRANO-(5',6'..3,4)-5,6,7,8-TETRAHYDROACRIDONE
    GOVINDACHARI, TR
    PAI, BR
    RAMACHAN.VN
    INDIAN JOURNAL OF CHEMISTRY, 1968, 6 (04): : 179 - +
  • [39] 7-deazainosine derivatives:: Synthesis and characterization of 7- and 7,8-substituted pyrrolo [2,3-d]pyrimidine ribonucleosides
    Ciliberti, Nunzia
    Durini, Elisa
    Manfredini, Stefano
    Vertuani, Silvia
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2008, 27 (05): : 525 - 533
  • [40] SYNTHESIS AND PHYSICAL-CHEMICAL PROPERTIES OF 7,8-DISUBSTITUTED 3-METHYLXANTHINE DERIVATIVES AND 2,6,7,8-TETRA-SUBSTITUTED PURINE DERIVATIVES
    PRIIMENKO, BA
    GNATOV, NI
    KLYUEV, NA
    ROMANENKO, NI
    IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 1986, 29 (02): : 35 - 38
12345