Synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetra- hydropyrido[3,4-d]pyrimidine

被引：0
|
作者：
Kuznetsov A.Yu. [1 ]
Chapyshev S.V. [1 ]
机构：
[1] Institute for Problems of Chemical Physics, Russian Academy of Sciences
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 10期
关键词：
Condensation; Ethyl; 1-benzyl-3-oxopiperidine-4-carboxylate; Pyridinecarboxyamidines; Pyrido[3,4-d]pyrimidines;
D O I：
10.1007/s10593-007-0200-0
中图分类号：
学科分类号：
摘要：
A method has been developed for the synthesis of 2-pyridyl-substituted derivatives of 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine based on the condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with pyridyl-2-, pyridyl-3-, and pyridyl-4-carboxamidines and subsequent reactions of 7-benzyl-2-pyridyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-ones with trifluoromethanesulfonic anhydride and secondary amines. © 2007 Springer Science+Business Media, Inc.
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页码：1320 / 1324
页数：4
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