Synthesis of 7-arylmethyl-substituted derivatives of 2-amino-2-pyrrolydin- 1-yl-5,6,7,8-tetrahydropyrido-[3,4-d]pyrimidine

被引：0

作者：

Kuznetsov A.Yu. ^{[1
]}

Chapyshev S.V. ^{[1
]}

机构：

[1] Institute of Problems of Chemical Physics, Russian Academy of Sciences

来源：

Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 9期

关键词：

1-benzyl-4-ethoxycarbonyl-3-oxopiperidine; Condensation; Pyrido[3,4-d]pyrimidines; Pyrrolidine-1-carboxamidine; Reductive amination; Sodium triacetoxyborohydride;

D O I：

10.1007/s10593-007-0179-6

中图分类号：

学科分类号：

摘要：

7-Benzyl-2-pyrrolidin-1-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d] pyrimidin-4-one was prepared by condensation of 1-benzyl-4-ethoxycarbonyl-3- oxopiperidine with pyrrolidine-1-carboxamidine. Subsequent treatment of the product with trifluoromethansulfonyl anhydride, aqueous ammonia, and hydrogen in the presence of palladium on carbon gave 4-amino-2-pyrrolidin-1-yl-5,6,7,8- tetrahydropyrido[3,4-d]pyrimidine in 80% yield. The given compound was used in the reductive amination of aldehydes in the synthesis of various 7-arylmethyl-substituted derivatives of 4-amino-2-pyrrolidin-1-yl-5,6,7,8- tetrahydropyrido[3,4-d]pyrimidine. © 2007 Springer Science+Business Media, Inc.

引用

页码：1167 / 1173

页数：6

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