Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine

被引：0
|
作者：
Zhang, Zhili [1 ]
Liu, Jie [1 ]
Liu, Weidong [1 ]
Wang, Xiaowei [1 ]
Cheng, Zhijian [3 ]
Liu, Junyi [1 ,2 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China
[3] Coll Jiujiang, Dept Chem, Jiujiang 33200, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 06期
关键词：
THYMIDYLATE SYNTHETASE; ANALOG; INHIBITOR; ACID;
D O I：
10.1002/jhet.197
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine 3 is described from 2-amino-6-methyluracil 4 through the crucial step of 2-pivaloyl protecting and cyclization. The assignment of the structure of 3 was performed by its spectral data, the H-1 NMR, C-13 NMR, gHMQC, and HRMS spectra.
引用
收藏
页码：1151 / 1153
页数：3
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