Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine

被引：0

作者：

Zhang, Zhili ^{[1
]}

Liu, Jie ^{[1
]}

Liu, Weidong ^{[1
]}

Wang, Xiaowei ^{[1
]}

Cheng, Zhijian ^{[3
]}

Liu, Junyi ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China

[3] Coll Jiujiang, Dept Chem, Jiujiang 33200, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 06期

关键词：

THYMIDYLATE SYNTHETASE; ANALOG; INHIBITOR; ACID;

D O I：

10.1002/jhet.197

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine 3 is described from 2-amino-6-methyluracil 4 through the crucial step of 2-pivaloyl protecting and cyclization. The assignment of the structure of 3 was performed by its spectral data, the H-1 NMR, C-13 NMR, gHMQC, and HRMS spectra.

引用

页码：1151 / 1153

页数：3

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