The Presence of a Fibrotic Focus in Invasive Breast Carcinoma Correlates with the Expression of Carbonic Anhydrase IX and is a Marker of Hypoxia and Poor Prognosis
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作者:
Cecile G. Colpaert
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机构:University Hospital Antwerp,Department of Pathology
Cecile G. Colpaert
Peter B. Vermeulen
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机构:University Hospital Antwerp,Department of Pathology
Peter B. Vermeulen
Stephen B. Fox
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机构:University Hospital Antwerp,Department of Pathology
Stephen B. Fox
Adrian L. Harris
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机构:University Hospital Antwerp,Department of Pathology
Adrian L. Harris
Luc Y. Dirix
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机构:University Hospital Antwerp,Department of Pathology
Luc Y. Dirix
Eric A. Van Marck
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机构:University Hospital Antwerp,Department of Pathology
Eric A. Van Marck
机构:
[1] University Hospital Antwerp,Department of Pathology
[2] University of Antwerp,Translational Cancer Research Group
[3] AZ Sint-Augustinus,John Radcliffe Hospital
[4] Weatherall Institute of Molecular Medicine,undefined
breast cancer;
carbonic anhydrase IX;
fibrotic focus;
hypoxia;
intra-tumoral fibroblasts;
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摘要:
The value of the fibrotic focus (FF) as a marker of intra-tumoral hypoxia in invasive breast carcinoma was assessed by studying its relationship with the expression of the hypoxia-induced carbonic anhydrase IX (CA IX), angiogenesis indices and prognosis.
机构:
Fudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R China
Hu, Chunyan
Wang, Huan
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Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, 83 Fen Yang Rd, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R China
Wang, Huan
Lin, Lan
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Fudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R China
Lin, Lan
Sun, Xicai
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Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, 83 Fen Yang Rd, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R China
Sun, Xicai
Wang, Dehui
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Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, 83 Fen Yang Rd, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Clin Pathol, Shanghai, Peoples R China
机构:
Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Mafodda, Antonino
Giuffrida, Raffaella
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Giuffrida, Raffaella
Mare, Marzia
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Mare, Marzia
Blanco, Giusi
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Blanco, Giusi
Munao, Stefania
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Munao, Stefania
Memeo, Lorenzo
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA
Memeo, Lorenzo
Giuffrida, Dario
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Ist Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USAIst Oncol Mediterraneo, Dipartimento Oncol Sperimentale, Viagrande, CT USA