The Presence of a Fibrotic Focus in Invasive Breast Carcinoma Correlates with the Expression of Carbonic Anhydrase IX and is a Marker of Hypoxia and Poor Prognosis

被引:0
|
作者
Cecile G. Colpaert
Peter B. Vermeulen
Stephen B. Fox
Adrian L. Harris
Luc Y. Dirix
Eric A. Van Marck
机构
[1] University Hospital Antwerp,Department of Pathology
[2] University of Antwerp,Translational Cancer Research Group
[3] AZ Sint-Augustinus,John Radcliffe Hospital
[4] Weatherall Institute of Molecular Medicine,undefined
来源
关键词
breast cancer; carbonic anhydrase IX; fibrotic focus; hypoxia; intra-tumoral fibroblasts;
D O I
暂无
中图分类号
学科分类号
摘要
The value of the fibrotic focus (FF) as a marker of intra-tumoral hypoxia in invasive breast carcinoma was assessed by studying its relationship with the expression of the hypoxia-induced carbonic anhydrase IX (CA IX), angiogenesis indices and prognosis.
引用
收藏
页码:137 / 147
页数:10
相关论文
共 50 条
  • [1] The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis
    Colpaert, CG
    Vermeulen, PB
    Fox, SB
    Harris, AL
    Dirix, LY
    Van Marck, EA
    BREAST CANCER RESEARCH AND TREATMENT, 2003, 81 (02) : 137 - 147
  • [2] Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma
    Huang, Wei-Ju
    Jeng, Yung-Ming
    Lai, Hong-Shiee
    Fong, Iok-U
    Sheu, Fang-Yu Bonnie
    Lai, Po-Lin
    Yuan, Ray-Hwang
    PLOS ONE, 2015, 10 (03):
  • [3] Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
    Chia, SK
    Wykoff, CC
    Watson, PH
    Han, C
    Leek, RD
    Pastorek, J
    Gatter, KC
    Ratcliffe, P
    Harris, AL
    JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (16) : 3660 - 3668
  • [4] Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
    Watson, PH
    Chia, SK
    Wykoff, CC
    Han, C
    Leek, RD
    Sly, WS
    Gatter, KC
    Ratcliffe, P
    Harris, AL
    BRITISH JOURNAL OF CANCER, 2003, 88 (07) : 1065 - 1070
  • [5] Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
    P H Watson
    S K Chia
    C C Wykoff
    C Han
    R D Leek
    W S Sly
    K C Gatter
    P Ratcliffe
    A L Harris
    British Journal of Cancer, 2003, 88 : 1065 - 1070
  • [6] Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
    S A Hussain
    R Ganesan
    G Reynolds
    L Gross
    A Stevens
    J Pastorek
    P G Murray
    B Perunovic
    M S Anwar
    L Billingham
    N D James
    D Spooner
    C J Poole
    D W Rea
    D H Palmer
    British Journal of Cancer, 2007, 96 : 104 - 109
  • [7] Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
    Hussain, S. A.
    Ganesan, R.
    Reynolds, G.
    Gross, L.
    Stevens, A.
    Pastorek, J.
    Murray, P. G.
    Perunovic, B.
    Anwar, M. S.
    Billingham, L.
    James, N. D.
    Spooner, D.
    Poole, C. J.
    Rea, D. W.
    Palmer, D. H.
    BRITISH JOURNAL OF CANCER, 2007, 96 (01) : 104 - 109
  • [8] Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma
    Måseide, K
    Kandel, RA
    Bell, RS
    Catton, CN
    O'Sullivan, B
    Wunder, JS
    Pintilie, M
    Hedley, D
    Hill, RP
    CLINICAL CANCER RESEARCH, 2004, 10 (13) : 4464 - 4471
  • [9] Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma
    N Tanaka
    H Kato
    T Inose
    H Kimura
    A Faried
    M Sohda
    M Nakajima
    Y Fukai
    T Miyazaki
    N Masuda
    M Fukuchi
    H Kuwano
    British Journal of Cancer, 2008, 99 : 1468 - 1475
  • [10] Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis
    Haapasalo, JA
    Nordfors, KM
    Hilvo, M
    Rantala, IJ
    Soini, Y
    Parkkila, AK
    Pastoreková, S
    Pastorek, J
    Parkkila, SM
    Haapasalo, HK
    CLINICAL CANCER RESEARCH, 2006, 12 (02) : 473 - 477