Phototransformation of fibrate drugs in aqueous media

被引：0
|
作者：
M. Cermola
M. DellaGreca
M.R. Iesce
L. Previtera
M. Rubino
F. Temussi
M. Brigante
机构：
[1] Università Federico II,Dipartimento di Chimica Organica e Biochimica
[2] UdR Napoli 4 of Consortium INCA,undefined
[3] Dipartimento di Scienze della Vita,undefined
来源：
Environmental Chemistry Letters | 2005年 / 3卷
关键词：
Bezafibrate. Gemfibrozil. Fenofibrate. Fenofibric acid. Drugs. Photodegradation. Solar-simulated irradiation.;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The photochemical conversion of bezafibrate, gemfibrozil, fenofibrate and fenofibric acid has been examined in aqueous media. Irradiation with a solar simulator in distilled water caused about 10% degradation for the first three drugs after 200 hr, while fenofibric acid was completely degraded after 100 hr. Experiments have also been performed in the presence of nitrates or humic acids, considered as environmental photosensitizers, and only for gemfibrozil a reduction of degradation has been observed. Photoproducts have been characterized and the mechanistic pathways discussed on the basis of experimental and literature data.
引用
收藏
页码：43 / 47
页数：4
相关论文
共 50 条
  • [31] Phototransformation of Oxamyl in the Presence of Natural Phosphate in Aqueous Solution
    El Gaini, L.
    Meghea, A.
    Hatim, Z.
    Bakasse, M.
    2008 2ND ICTON MEDITERRANEAN WINTER (ICTON-MW), 2008, : 89 - 89
  • [32] Study of the phototransformation of imazaquin in aqueous solution: a kinetic approach
    Barkani, H
    Catastini, C
    Emmelin, C
    Sarakha, M
    El Azzouzi, A
    Chovelon, JM
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2005, 170 (01) : 27 - 35
  • [33] Phototransformation of anthraquinone-2-sulphonate in aqueous solution
    Andrea Bedini
    Elisa De Laurentiis
    Babita Sur
    Valter Maurino
    Claudio Minero
    Marcello Brigante
    Gilles Mailhot
    Davide Vione
    Photochemical & Photobiological Sciences, 2012, 11 : 1445 - 1453
  • [34] Phototransformation of 1,4-naphthoquinone in aqueous solution
    Ouarda Brahmia
    Claire Richard
    Photochemical & Photobiological Sciences, 2003, 2 : 1038 - 1043
  • [35] Phototransformation of anthraquinone-2-sulphonate in aqueous solution
    Bedini, Andrea
    De Laurentiis, Elisa
    Sur, Babita
    Maurino, Valter
    Minero, Claudio
    Brigante, Marcello
    Mailhot, Gilles
    Vione, Davide
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2012, 11 (09) : 1445 - 1453
  • [36] Phototransformation of 1,4-naphthoquinone in aqueous solution
    Brahmia, O
    Richard, C
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2003, 2 (10) : 1038 - 1043
  • [37] Phototransformation of selected organophosphorus pesticides in dilute aqueous solutions
    Zamy, C
    Mazellier, P
    Legube, B
    WATER RESEARCH, 2004, 38 (09) : 2305 - 2314
  • [38] Analysis of Some Fibrate-Type Antihyperlipidemic Drugs by AMD
    Wojciech Markowski
    Katarzyna L. Czapińska
    Genowefa Misztal
    Łukasz Komsta
    JPC – Journal of Planar Chromatography – Modern TLC, 2006, 19 : 260 - 266
  • [39] PHOTOTRANSFORMATION OF MEROCYANINE FORMS OF SPIROPYRANS IN AMORPHOUS POLYMERIC MEDIA
    UZNANSKI, P
    WOJDA, A
    KRYSZEWSKI, M
    EUROPEAN POLYMER JOURNAL, 1990, 26 (02) : 141 - 143
  • [40] Photodegradation of sulfamethazine, sulfamethoxypiridazine, amitriptyline, and clomipramine drugs in aqueous media
    Nassar, Rania
    Trivella, Aurelien
    Mokh, Samia
    Al-Iskandarani, Mohamad
    Budzinski, Helene
    Mazellier, Patrick
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2017, 336 : 176 - 182
12345