Phototransformation of fibrate drugs in aqueous media

被引：0
|
作者：
M. Cermola
M. DellaGreca
M.R. Iesce
L. Previtera
M. Rubino
F. Temussi
M. Brigante
机构：
[1] Università Federico II,Dipartimento di Chimica Organica e Biochimica
[2] UdR Napoli 4 of Consortium INCA,undefined
[3] Dipartimento di Scienze della Vita,undefined
来源：
Environmental Chemistry Letters | 2005年 / 3卷
关键词：
Bezafibrate. Gemfibrozil. Fenofibrate. Fenofibric acid. Drugs. Photodegradation. Solar-simulated irradiation.;
D O I：
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中图分类号：
学科分类号：
摘要：
The photochemical conversion of bezafibrate, gemfibrozil, fenofibrate and fenofibric acid has been examined in aqueous media. Irradiation with a solar simulator in distilled water caused about 10% degradation for the first three drugs after 200 hr, while fenofibric acid was completely degraded after 100 hr. Experiments have also been performed in the presence of nitrates or humic acids, considered as environmental photosensitizers, and only for gemfibrozil a reduction of degradation has been observed. Photoproducts have been characterized and the mechanistic pathways discussed on the basis of experimental and literature data.
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页码：43 / 47
页数：4
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