L-proline: a highly effective cryoprotectant for mouse oocyte vitrification

被引：0

作者：

Lu Zhang

Xu Xue

Jie Yan

Li-Ying Yan

Xiao-Hu Jin

Xiao-Hui Zhu

Zhi-Zhu He

Jing Liu

Rong Li

Jie Qiao

机构：

[1] Center for Reproductive Medicine,Department of Obstetrics and Gynecology

[2] Peking University Third Hospital,Department of Biomedical Engineering

[3] Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction,undefined

[4] Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics,undefined

[5] Technical Institute of Physics and Chemistry,undefined

[6] Chinese Academy of Sciences,undefined

[7] Key Laboratory of Assisted Reproduction,undefined

[8] Ministry of Education,undefined

[9] School of Medicine,undefined

[10] Tsinghua University,undefined

来源：

Scientific Reports | / 6卷

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摘要：

Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.

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