L-proline: a highly effective cryoprotectant for mouse oocyte vitrification

被引：0
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作者：
Lu Zhang
Xu Xue
Jie Yan
Li-Ying Yan
Xiao-Hu Jin
Xiao-Hui Zhu
Zhi-Zhu He
Jing Liu
Rong Li
Jie Qiao
机构：
[1] Center for Reproductive Medicine,Department of Obstetrics and Gynecology
[2] Peking University Third Hospital,Department of Biomedical Engineering
[3] Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction,undefined
[4] Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics,undefined
[5] Technical Institute of Physics and Chemistry,undefined
[6] Chinese Academy of Sciences,undefined
[7] Key Laboratory of Assisted Reproduction,undefined
[8] Ministry of Education,undefined
[9] School of Medicine,undefined
[10] Tsinghua University,undefined
来源：
Scientific Reports | / 6卷
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摘要：
Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.
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