Microglial microRNAs mediate sex-specific responses to tau pathology

被引：0
|
作者：
Lay Kodama
Elmer Guzman
Jon I. Etchegaray
Yaqiao Li
Faten A. Sayed
Lu Zhou
Yungui Zhou
Lihong Zhan
David Le
Joe C. Udeochu
Claire D. Clelland
Zuolin Cheng
Guoqiang Yu
Qingyun Li
Kenneth S. Kosik
Li Gan
机构：
[1] University of California,Neuroscience Graduate Program
[2] San Francisco,Medical Scientist Training Program and Neuroscience Graduate Program
[3] Gladstone Institute of Neurological Disease,Department of Molecular, Cell and Developmental Biology
[4] Helen and Robert Appel Alzheimer’s Disease Research Institute,Neuroscience Research Institute
[5] Brain and Mind Research Institute,Department of Neurobiology
[6] Weill Cornell Medicine,Department of Neurobiology
[7] University of California,Bradley Department of Electrical and Computer Engineering
[8] San Francisco,undefined
[9] University of California,undefined
[10] Santa Barbara,undefined
[11] University of California,undefined
[12] Santa Barbara,undefined
[13] Stanford University School of Medicine,undefined
[14] University of California,undefined
[15] San Francisco,undefined
[16] Virginia Polytechnic Institute and State University,undefined
来源：
Nature Neuroscience | 2020年 / 23卷
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摘要：
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
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页码：167 / 171
页数：4
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