Microglial microRNAs mediate sex-specific responses to tau pathology

被引：0
|
作者：
Lay Kodama
Elmer Guzman
Jon I. Etchegaray
Yaqiao Li
Faten A. Sayed
Lu Zhou
Yungui Zhou
Lihong Zhan
David Le
Joe C. Udeochu
Claire D. Clelland
Zuolin Cheng
Guoqiang Yu
Qingyun Li
Kenneth S. Kosik
Li Gan
机构：
[1] University of California,Neuroscience Graduate Program
[2] San Francisco,Medical Scientist Training Program and Neuroscience Graduate Program
[3] Gladstone Institute of Neurological Disease,Department of Molecular, Cell and Developmental Biology
[4] Helen and Robert Appel Alzheimer’s Disease Research Institute,Neuroscience Research Institute
[5] Brain and Mind Research Institute,Department of Neurobiology
[6] Weill Cornell Medicine,Department of Neurobiology
[7] University of California,Bradley Department of Electrical and Computer Engineering
[8] San Francisco,undefined
[9] University of California,undefined
[10] Santa Barbara,undefined
[11] University of California,undefined
[12] Santa Barbara,undefined
[13] Stanford University School of Medicine,undefined
[14] University of California,undefined
[15] San Francisco,undefined
[16] Virginia Polytechnic Institute and State University,undefined
来源：
Nature Neuroscience | 2020年 / 23卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
引用
收藏
页码：167 / 171
页数：4
相关论文
共 50 条
  • [31] Sex-specific responses of Populus deltoides to defoliation
    Li Shuxin
    Yu Lei
    Duan Baoli
    Peng Shuming
    ACTA SOCIETATIS BOTANICORUM POLONIAE, 2017, 86 (04)
  • [32] Sex-specific, counteracting responses to inbreeding in a bird
    Pizzari, T
    Lovlie, H
    Cornwallis, CK
    PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2004, 271 (1553) : 2115 - 2121
  • [33] Microglial function interacts with the environment to affect sex-specific depression risk
    Fitzgerald, Eamon
    Pokhvisneva, Irina
    Patel, Sachin
    Chan, Shi Yu
    Tan, Ai Peng
    Chen, Helen
    Silveira, Patricia Pelufo
    Meaney, Michael J.
    BRAIN BEHAVIOR AND IMMUNITY, 2024, 119 : 597 - 606
  • [34] Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease
    Acosta-Martinez, Maricedes
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2020, 375 (01): : 223 - 236
  • [35] Sex-Specific Microglial Responses to Glucocerebrosidase Inhibition: Relevance to GBA1-Linked Parkinson's Disease
    Brunialti, Electra
    Villa, Alessandro
    Toffoli, Marco
    Del Pozo, Sara Lucas
    Rizzi, Nicoletta
    Meda, Clara
    Maggi, Adriana
    Schapira, Anthony H. V.
    Ciana, Paolo
    CELLS, 2023, 12 (03)
  • [36] Mitochondrial networks reveal sex-specific microglial response to stress and injury
    Maes, M.
    Colombo, G.
    Schoot-Uiterkamp, F.
    Venturino, A.
    Sternberg, F.
    Pohl, E.
    Siegert, S.
    GLIA, 2023, 71 : E275 - E275
  • [37] Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner
    Walker, Katherine A.
    Rhodes, Simone T.
    Liberman, Deborah A.
    Gore, Andrea C.
    Bell, Margaret R.
    NEUROTOXICOLOGY, 2024, 104 : 95 - 115
  • [38] MicroRNAs Mediate Autoimmune Disease Pathology
    Smith, Kristen
    Liu, Chang-Gong
    Williams, Jessica
    Kithcart, Aaron
    Gienapp, Ingrid
    Shawler, Todd
    Song, Fei
    Whitacre, Caroline
    FASEB JOURNAL, 2008, 22
  • [39] MicroRNAs mediate autoimmune disease pathology
    Smith, Kristen M.
    Liu, Chang-gong
    Taccioli, Cristian
    Williams, Jessica
    Kithcart, Aaron
    Mavrikis, Gina
    Shawler, Todd
    Whitacre, Caroline C.
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [40] Shoulder and elbow pathology in the female athlete: sex-specific considerations
    Wessel, Lauren E.
    Eliasberg, Claire D.
    Bowen, Edward
    Sutton, Karen M.
    JOURNAL OF SHOULDER AND ELBOW SURGERY, 2021, 30 (05) : 977 - 985
12345