Microglial microRNAs mediate sex-specific responses to tau pathology

被引：0

作者：

Lay Kodama

Elmer Guzman

Jon I. Etchegaray

Yaqiao Li

Faten A. Sayed

Lu Zhou

Yungui Zhou

Lihong Zhan

David Le

Joe C. Udeochu

Claire D. Clelland

Zuolin Cheng

Guoqiang Yu

Qingyun Li

Kenneth S. Kosik

Li Gan

机构：

[1] University of California,Neuroscience Graduate Program

[2] San Francisco,Medical Scientist Training Program and Neuroscience Graduate Program

[3] Gladstone Institute of Neurological Disease,Department of Molecular, Cell and Developmental Biology

[4] Helen and Robert Appel Alzheimer’s Disease Research Institute,Neuroscience Research Institute

[5] Brain and Mind Research Institute,Department of Neurobiology

[6] Weill Cornell Medicine,Department of Neurobiology

[7] University of California,Bradley Department of Electrical and Computer Engineering

[8] San Francisco,undefined

[9] University of California,undefined

[10] Santa Barbara,undefined

[11] University of California,undefined

[12] Santa Barbara,undefined

[13] Stanford University School of Medicine,undefined

[14] University of California,undefined

[15] San Francisco,undefined

[16] Virginia Polytechnic Institute and State University,undefined

来源：

Nature Neuroscience | 2020年 / 23卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

引用

页码：167 / 171

页数：4

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